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BRL-52537

BRL-52537
IUPAC ime
2-(3,4-diclorofenil)-1-[(2S)-2-(pirolidin-1-ilmetil)piperidin-1-il]etanon
Identifikatori
CAS broj130497-33-5 ДаY
ATC kodnone
PubChemCID 6603740
Hemijski podaci
FormulaC18H24Cl2N2O
Molarna masa355.301 g/mol
  • C1CCN([C@@H](C1)CN2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl

BRL-52537 je lek koji deluje kao potentan i visoko selektivan κ-opioidni agonist.[1] On je pokazao neuroprotektivno dejstvo u studijama na životinjama,[2][3] i koristi se za istraživanje potencijalnih tretmana za moždani i srčani udar, kao i za neka uopštenija istraživanja mozga.[4][5][6]

Reference

  1. ^ Vecchietti V, Giordani A, Giardina G, Colle R, Clarke GD (1991). „(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics”. Journal of Medicinal Chemistry. 34 (1): 397—403. PMID 1846921. 
  2. ^ Goyagi T, Toung TJ, Kirsch JR, Traystman RJ, Koehler RC, Hurn PD, Bhardwaj A (2003). „Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats”. Stroke; a Journal of Cerebral Circulation. 34 (6): 1533—8. PMID 12738895. doi:10.1161/01.STR.0000072512.30658.E7. 
  3. ^ Zhang Z, Chen TY, Kirsch JR, Toung TJ, Traystman RJ, Koehler RC, Hurn PD, Bhardwaj A (2003). „Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats”. Anesthesia and Analgesia. 97 (6): 1776—83. PMID 14633559. 
  4. ^ Chen TY, Goyagi T, Toung TJ, Kirsch JR, Hurn PD, Koehler RC, Bhardwaj A (2004). „Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats”. Stroke; a Journal of Cerebral Circulation. 35 (5): 1180—5. PMID 15031456. doi:10.1161/01.STR.0000125011.93188.c6. 
  5. ^ Peart JN, Gross ER, Gross GJ (2004). „Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction”. Journal of Cardiovascular Pharmacology. 43 (3): 410—5. PMID 15076225. 
  6. ^ Britt JP, McGehee DS (2008). „Presynaptic opioid and nicotinic receptor modulation of dopamine overflow in the nucleus accumbens”. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 28 (7): 1672—81. PMID 18272687. doi:10.1523/JNEUROSCI.4275-07.2008. 

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