Flavivirin (EC 3.4.21.91, proteaza virusa žute groznice (flavi virusa), NS2B-3 proteinaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Selectivna hidroliza -Xaa-Xaa-Yaa- veza u kojima Xaa može da bude bilo Arg ili Lys i Yaa može da bude bilo Ser ili Ala
Ovaj enzim je poznat iz klasičnih flavivirusa (žuta groznica, denga groznica).
Reference
- ^ Chambers, T.J., Hahn, C.S., Galler, R. and Rice, C.M. (1990). „Flavivirus genome organization, expression, and replication”. Annu. Rev. Microbiol. 44: 649—688. PMID 2174669.
- ^ Cahour, A., Falgout, B. and Lai, C.-J. (1992). „Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease”. J. Virol. 66: 1535—1542. PMID 1531368.
- ^ Lin, C., Amberg, S.M., Chambers, T.J. and Rice, C.M. (1993). „Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site”. J. Virol. 67: 2327—2335. PMID 8445732.
Literatura
Spoljašnje veze
- Flavivirin на US National Library of Medicine Medical Subject Headings (MeSH)
