Glicerofosfoinozitolna inozitolfosfodiestaraza

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Glicerofosfoinozitolna inozitolfosfodiestaraza
Glicerofosfoinozitolna inozitolfosfodiestaraza
Identifikatori
EC broj	3.1.4.43
CAS broj	9076-91-9 (from EC 3.1.4.36), 72414-13-2 (not distinguished from EC 3.1.4.44)
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Glicerofosfoinozitolna inozitolfosfodiestaraza (EC 3.1.4.43, 1,2-ciklična-inozitol-fosfatna fosfodiesteraza, D-mio-inozitol 1:2-ciklična fosfat 2-fosfohidrolaza, D-inozitol 1,2-ciklična fosfat 2-fosfohidrolaza, D-mio-inozitol 1,2-ciklična fosfat 2-fosfohidrolaza, 1-D-mio-inozitol-1,2-ciklična-fosfat 2-inozitolfosfohidrolaza, inozitol-1,2-ciklična-fosfat 2-inozitolfosfohidrolaza) je enzim sa sistematskim imenom 1-(sn-glicero-3-fosfo)-1D-mio-inozitol inozitolfosfohidrolaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

1-(sn-glicero-3-fosfo)-1D-mio-inozitol + H₂O

\rightleftharpoons

glicerol + 1D-mio-inozitol 1-fosfat

Ovaj enzim takođe hidrolizuje Ins(ciklična1,2)P do Ins-1-P

Reference

^ Dawson, R.M.C. & Hemington, N. (1977). „A phosphodiesterase in rat kidney cortex that hydrolyses glycerylphosphorylinositol”. Biochem. J. 162: 241—245. PMID 192216.
^ Dawson, R.M.C. & Clarke, N.G. (1972). „D-myoInositol 1:2-cyclic phosphate 2-phosphohydrolase”. Biochem. J. 127: 113—118. PMID 4342209.
^ Dawson, R.M.C. & Clarke, N.G. (1973). „A comparison of D-inositol 1:2-cyclic phosphate 2-phosphohydrolase with other phosphodiesterases of kidney”. Biochem. J. 134: 59—67. PMID 4353088.
^ Ross, T.S. & Majerus, P.W. (1991). „Inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase. Substrate specificity and regulation of activity by phospholipids, metal ion chelators, and inositol 2-phosphate”. J. Biol. Chem. 266: 851—856. PMID 1845995.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Glycerophosphoinositol+inositolphosphodiesterase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Dawson, R.M.C. & Hemington, N. (1977). „A phosphodiesterase in rat kidney cortex that hydrolyses glycerylphosphorylinositol”. Biochem. J. 162: 241—245. PMID 192216.

[2] Dawson, R.M.C. & Clarke, N.G. (1972). „D-myoInositol 1:2-cyclic phosphate 2-phosphohydrolase”. Biochem. J. 127: 113—118. PMID 4342209.

[3] Dawson, R.M.C. & Clarke, N.G. (1973). „A comparison of D-inositol 1:2-cyclic phosphate 2-phosphohydrolase with other phosphodiesterases of kidney”. Biochem. J. 134: 59—67. PMID 4353088.

[4] Ross, T.S. & Majerus, P.W. (1991). „Inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase. Substrate specificity and regulation of activity by phospholipids, metal ion chelators, and inositol 2-phosphate”. J. Biol. Chem. 266: 851—856. PMID 1845995.

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