Izohinolin 1-oksidoreduktaza

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PMC	članci
PubMed	članci
NCBI	proteini

Izohinolin 1-oksidoreduktaza
Izohinolin 1-oksidoreduktaza
Identifikatori
EC broj	1.3.99.16
CAS broj	155948-73-5
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Izohinolin 1-oksidoreduktaza (EC 1.3.99.16, izohinolinska 1-oksidoreduktaza) je enzim sa sistematskim imenom izohinolin:akceptor 1-oksidoreduktaza (hidroksilacija).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

izohinolin + akceptor +H₂O

\rightleftharpoons

izohinolin-1(2H)-on + redukovani akceptor

Ovaj enzim iz Pseudomonas diminuta je specifičan za N-heterociklične supstrate, uključujući izohinolin, izohinolin-5-ol, ftalazin i hinazolin. Elektronski akceptori su 1,2-benzohinon, citohrom c, fericijanid, jodonitrotetrazolijum hlorid, nitroplavo tetrazolijum, Meldola plavo i fenazin metosulfat.

Reference

^ Lehmann, M., Tshisuaka, B., Fetzner, S., Roger, P. and Lingens, F. (1994). „Purification and characterization of isoquinoline 1-oxidoreductase from Pseudomonas diminuta 7, a novel molybdenum-containing hydroxylase”. J. Biol. Chem. 269: 11254—11260. PMID 8157655.
^ Lehmann, M., Tshisuaka, B., Fetzner, S. and Lingens, F. (1995). „Molecular cloning of the isoquinoline 1-oxidoreductase genes from Pseudomonas diminuta 7, structural analysis of iorA and iorB, and sequence comparisons with other molybdenum-containing hydroxylases”. J. Biol. Chem. 270: 14420—14429. PMID 7782304.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Isoquinoline+1-oxidoreductase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Lehmann, M., Tshisuaka, B., Fetzner, S., Roger, P. and Lingens, F. (1994). „Purification and characterization of isoquinoline 1-oxidoreductase from Pseudomonas diminuta 7, a novel molybdenum-containing hydroxylase”. J. Biol. Chem. 269: 11254—11260. PMID 8157655.

[2] Lehmann, M., Tshisuaka, B., Fetzner, S. and Lingens, F. (1995). „Molecular cloning of the isoquinoline 1-oxidoreductase genes from Pseudomonas diminuta 7, structural analysis of iorA and iorB, and sequence comparisons with other molybdenum-containing hydroxylases”. J. Biol. Chem. 270: 14420—14429. PMID 7782304.

[1]

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