Kaspaza-11

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Kaspaza-11
Kaspaza-11
Identifikatori
EC broj	3.4.22.64
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Kaspaza-11 (EC 3.4.22.64, CASP-11) je enzim.^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Neophodno je prisustvo Asp ostatka u P1 poziciji. Preferentno dolazi do razlaganja sekvence (Ile/Leu/Val/Phe)-Gly-His-Asp-

Ovaj murinski enzim je deo familije inflamatornih kaspaza, u koji se takođe ubrajaju kaspaza-1 (EC 3.4.22.36), kaspaza-4 (EC 3.4.22.57) i kaspaza-5 (EC 3.4.22.58) kod ljudi i kaspaza-12, kaspaza-13 i kaspaza-14 kod miševa.

Reference

^ Kang, S.J., Wang, S., Hara, H., Peterson, E.P., Namura, S., Amin-Hanjani, S., Huang, Z., Srinivasan, A., Tomaselli, K.J., Thornberry, N.A., Moskowitz, M.A. and Yuan, J. (2000). „Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions”. J. Cell. Biol. 149: 613—622. PMID 10791975.
^ Hur, J., Kim, S.Y., Kim, H., Cha, S., Lee, M.S. and Suk, K. (2001). „Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway”. FEBS Lett. 507: 157—162. PMID 11684090.
^ Wang, S., Miura, M., Jung, Y.K., Zhu, H., Li, E. and Yuan, J. (1998). „Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE”. Cell. 92: 501—509. PMID 9491891.
^ Endo, M., Mori, M., Akira, S. and Gotoh, T. (2006). „C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation”. J. Immunol. 176: 6245—6253. PMID 16670335.
^ Chang, H.Y. & Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821—846. PMID 11104820.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Caspase-11 на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Kang, S.J., Wang, S., Hara, H., Peterson, E.P., Namura, S., Amin-Hanjani, S., Huang, Z., Srinivasan, A., Tomaselli, K.J., Thornberry, N.A., Moskowitz, M.A. and Yuan, J. (2000). „Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions”. J. Cell. Biol. 149: 613—622. PMID 10791975.

[2] Hur, J., Kim, S.Y., Kim, H., Cha, S., Lee, M.S. and Suk, K. (2001). „Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway”. FEBS Lett. 507: 157—162. PMID 11684090.

[3] Wang, S., Miura, M., Jung, Y.K., Zhu, H., Li, E. and Yuan, J. (1998). „Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE”. Cell. 92: 501—509. PMID 9491891.

[4] Endo, M., Mori, M., Akira, S. and Gotoh, T. (2006). „C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation”. J. Immunol. 176: 6245—6253. PMID 16670335.

[5] Chang, H.Y. & Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821—846. PMID 11104820.

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