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Kotinin

Kotinin
IUPAC ime
(5S)-1-metil-5-(3-piridil)pirolidin-2-on
Klinički podaci
Način primeneOralno, pušenjem
Pravni status
Pravni status
  • ℞ (Prescription only)
Farmakokinetički podaci
Poluvreme eliminacije20 sata
Identifikatori
CAS broj486-56-6 ДаY
ATC kodnone
PubChemCID 854019
ChemSpider746405 ДаY
UNIIK5161X06LL ДаY
ChEMBLCHEMBL578211 ДаY
Hemijski podaci
FormulaC10H12N2O
Molarna masa176,22 g/mol
  • O=C2N(C)[C@H](c1cnccc1)CC2
  • InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1 ДаY
  • Key:UIKROCXWUNQSPJ-VIFPVBQESA-N ДаY

Kotinin je alkaloid prisutan u duvanu i kao metabolit nikotina.[1][2] Reč "kotinin" je anagram "nikotina". Kotinin se koristi kao biomarker za izlaganje duvanskom dimu. On je u prodaji kao antidepresiv pod imenom Scotine.[1]

Slično nikotinu, kotinin se vezuje za, aktivira, i desenzituje neuronski nikotinske acetilholinske receptore, mada sa znatno nižom potentnošću.[2][3][4][5] On ispoljava nootropne i antipsihoticima slične efekte.[6][7]

Reference

  1. ^ а б Triggle, David J. (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. 
  2. ^ а б Dwoskin LP, Teng L, Buxton ST, Crooks PA (1999). „(S)-(-)-Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H]dopamine release from rat striatal slices in a calcium-dependent manner”. The Journal of Pharmacology and Experimental Therapeutics. 288 (3): 905—11. PMID 10027825. 
  3. ^ Anderson DJ, Arneric SP (1994). „Nicotinic receptor binding of [3H]cytisine, [3H]nicotine and [3H]methylcarbamylcholine in rat brain”. European Journal of Pharmacology. 253 (3): 261—7. PMID 8200419. doi:10.1016/0014-2999(94)90200-3. 
  4. ^ Briggs CA, McKenna DG (1998). „Activation and inhibition of the human alpha7 nicotinic acetylcholine receptor by agonists”. Neuropharmacology. 37 (9): 1095—102. PMID 9833639. doi:10.1016/S0028-3908(98)00110-5. 
  5. ^ Buccafusco JJ, Shuster LC, Terry AV (2007). „Disconnection between activation and desensitization of autonomic nicotinic receptors by nicotine and cotinine”. Neuroscience Letters. 413 (1): 68—71. PMID 17157984. doi:10.1016/j.neulet.2006.11.028. 
  6. ^ Buccafusco JJ, Terry AV (2009). „A reversible model of the cognitive impairment associated with schizophrenia in monkeys: potential therapeutic effects of two nicotinic acetylcholine receptor agonists”. Biochemical Pharmacology. 78 (7): 852—62. PMID 19577545. doi:10.1016/j.bcp.2009.06.102. 
  7. ^ Buccafusco JJ, Beach JW, Terry AV (2009). „Desensitization of nicotinic acetylcholine receptors as a strategy for drug development”. The Journal of Pharmacology and Experimental Therapeutics. 328 (2): 364—70. PMC 2682277 Слободан приступ. PMID 19023041. doi:10.1124/jpet.108.145292. 

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