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Naltriben

Naltriben
Identifikatori
CAS broj111555-58-9
ATC kodnone
PubChemCID 5486827
IUPHAR/BPS1640
ChemSpider4589081 ДаY
Hemijski podaci
FormulaC26H25NO4
Molarna masa415.480 g/mol
  • Oc3c2O[C@H]6c1oc8ccccc8c1C[C@@]5(O)[C@H]4N(CC[C@@]56c2c(cc3)C4)CC7CC7
  • InChI=1S/C26H25NO4/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2/t20-,24+,25+,26-/m1/s1 ДаY
  • Key:ZHVWWEYETMPAMX-IFKAHUTRSA-N ДаY

Naltriben je potentan i selektivan antagonist delta opioidnog receptora, koji se koristi u naučnim istraživanjima. On ima slične efekte sa δ antagonistom naltrindolom koji je u široj upotrebi. Naltriben ima različit afinitet vezivanja za δ1 i δ2 tipove, iz kog razloga je koristan u određivanju osobina receptorskih izofromi.[1] On takođe deluje kao κ-opioidni agonist u visokim dozama.[2]

Reference

  1. ^ Sofuoglu, M.; Portoghese, P. S.; Takemori, A. E. (1991). „Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: Evidence for delta opioid receptor subtypes”. The Journal of Pharmacology and Experimental Therapeutics. 257 (2): 676—80. PMID 1851833. 
  2. ^ Stewart, P. E.; Holper, E. M.; Hammond, D. L. (1994). „Delta antagonist and kappa agonist activity of Naltriben: Evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes”. Life Sciences. 55 (4): PL79—84. PMID 8028443. doi:10.1016/0024-3205(94)00738-1. 

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