喹硫平

喹硫平
臨床資料
商品名（英语：Drug nomenclature）	思瑞康; Seroquel
MedlinePlus	a698019
懷孕分級	澳: B3 ; ;
给药途径	口服
ATC碼	N05AH04 (WHO) ;
法律規範狀態
法律規範	澳：限医生处方（S4）; 加：处方药（℞-only）; 英：处方药（℞-only） (POM); 美：处方药（℞-only）;
藥物動力學數據
生物利用度	9%
血漿蛋白結合率	83%
药物代谢	肝臟
生物半衰期	6 hours
排泄途徑	肾脏 (73%)、粪便 (20%)
识别信息
	IUPAC命名法 2-(2-(4-Dibenzo[b,f][1,4]thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol; ;
CAS号	111974-69-7
PubChem CID	5002;
IUPHAR/BPS	50;
DrugBank	DB01224 ;
ChemSpider	4827 ;
UNII	BGL0JSY5SI;
KEGG	D08456 ;
ChEBI	CHEBI:8707 ;
ChEMBL	ChEMBL716 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID9023546 ;
ECHA InfoCard	100.131.193
化学信息
化学式	C21H25N3O2S
摩尔质量	383.51 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
水溶性	3.29 mg/mL (20 °C)
	SMILES N\1=C(\c3c(Sc2c/1cccc2)cccc3)N4CCN(CCOCCO)CC4;
	InChI InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2 ; Key:URKOMYMAXPYINW-UHFFFAOYSA-N ;

喹硫平（INN：quetiapine）是非典型抗精神病藥物，常見商品名思瑞康（Seroquel），主要治療思覺失調症、雙相情緒障礙症，以及重性抑鬱疾患^[5]^[6]。此药仿單外使用包括鎮定、睡眠障礙；尽管临床上利用其镇静效果而可助眠，但这种方式所得的好处可能不会超过其不良副作用的坏处^[7]。

在全世界年銷售額約47億美元，且在美國達29億美元。^[8]專利權在美國，在2011年到期，而小兒科的範圍上，在2012年3月26日到期。^[9]這藥物的專利權已在加拿大到期。許多藥廠現在正製造喹硫平的學名藥。喹硫平的學名藥由Specifar ABEE，雅典，希臘製造和銷售。^[10]

喹硫平于1985年开发，1997年被批准在美国用于医疗用途。^[5]^[11]它可以作为一种通用名药物使用。^[12]2020年，它是美国第64种最常见的處方藥，有超过1000万张处方。^[13]^[14]

參考文獻

^ ^1.0 ^1.1 Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics. electronic Medicines Compendium. Sandoz. January 2013 [2013-10-20]. （原始内容存档于2013-10-20）.
^ quetiapine (Rx) - Seroquel, Seroquel XR. Medscape Reference. WebMD. [2013-10-11]. （原始内容存档于2013-10-20）.
^ Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.
^ QUETIAPINE FUMARATE tablet QUETIAPINE FUMARATE (quetiapine fumarate ) tablet [Ascend Laboratories, LLC]. DailyMed. Ascend Laboratories, LLC. October 2013 [2013-11-26]. （原始内容存档于2013-12-02）.
^ ^5.0 ^5.1 Quetiapine Fumarate. The American Society of Health-System Pharmacists. [26 March 2017]. （原始内容存档于29 August 2017）.
^ Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S. Second-generation antipsychotics for major depressive disorder and dysthymia. The Cochrane Database of Systematic Reviews. December 2010, (12): CD008121. PMID 21154393. doi:10.1002/14651858.CD008121.pub2.
^ Anderson SL, Vande Griend JP. Quetiapine for insomnia: A review of the literature (PDF). American Journal of Health-System Pharmacy. March 2014, 71 (5): 394–402. PMID 24534594. S2CID 207292819. doi:10.2146/ajhp130221. （原始内容 (PDF)存档于19 February 2020）.
^ Details for Seroquel. [2010-05-30]. （原始内容存档于2012-03-15）.
^ Seroquel patent expiration. [2010-05-30]. （原始内容存档于2012-03-15）.
^ Quepin Full Prescribing Information in Drug Reference Encyclopedia. [2010-04-03]. （原始内容存档于2016-11-07）. .
^ Riedel M, Müller N, Strassnig M, Spellmann I, Severus E, Möller HJ. Quetiapine in the treatment of schizophrenia and related disorders. Neuropsychiatric Disease and Treatment. April 2007, 3 (2): 219–235. PMC 2654633 . PMID 19300555. doi:10.2147/nedt.2007.3.2.219.
^ British national formulary : BNF 74 74. British Medical Association. 2017: 383. ISBN 978-0857112989.
^ The Top 300 of 2020. ClinCalc. [7 October 2022]. （原始内容存档于2021-02-12）.
^ Quetiapine - Drug Usage Statistics. ClinCalc. [7 October 2022]. （原始内容存档于2023-01-05）.

外部連結

Quetiapine. MedlinePlus. The American Society of Health-System Pharmacists, Inc. 2008-09-01 [2016-04-26]. （原始内容存档于2016-07-04）.
NAMI summary
Internet Drug List summary
Compound #1802: Quetiapine ChemBank
U.S. National Library of Medicine: Drug Information Portal - Quetiapine（页面存档备份，存于互联网档案馆）
Seroquel Adverse Events Reported to the FDA（页面存档备份，存于互联网档案馆）
Australian Public Assessment Report for Quetiapine (as fumarate)

Template:Navbox with collapsible groups WARNING: template omitted, post-expand include size too large --> #invoke: Navbox WARNING: template omitted, post-expand include size too large --> Template:Mood stabilizers WARNING: template omitted, post-expand include size too large --> Template:Hypnotics and sedatives WARNING: template omitted, post-expand include size too large -->

[EMC-1] 1.0 ^1.1 Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics. electronic Medicines Compendium. Sandoz. January 2013 [2013-10-20]. （原始内容存档于2013-10-20）.

[Medscape-2] quetiapine (Rx) - Seroquel, Seroquel XR. Medscape Reference. WebMD. [2013-10-11]. （原始内容存档于2013-10-20）.

[DD-3] Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.

[DM-4] QUETIAPINE FUMARATE tablet QUETIAPINE FUMARATE (quetiapine fumarate ) tablet [Ascend Laboratories, LLC]. DailyMed. Ascend Laboratories, LLC. October 2013 [2013-11-26]. （原始内容存档于2013-12-02）.

[AHFS2017-5] 5.0 ^5.1 Quetiapine Fumarate. The American Society of Health-System Pharmacists. [26 March 2017]. （原始内容存档于29 August 2017）.

[Cochrane2010-6] Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S. Second-generation antipsychotics for major depressive disorder and dysthymia. The Cochrane Database of Systematic Reviews. December 2010, (12): CD008121. PMID 21154393. doi:10.1002/14651858.CD008121.pub2.

[7] Anderson SL, Vande Griend JP. Quetiapine for insomnia: A review of the literature (PDF). American Journal of Health-System Pharmacy. March 2014, 71 (5): 394–402. PMID 24534594. S2CID 207292819. doi:10.2146/ajhp130221. （原始内容 (PDF)存档于19 February 2020）.

[8] Details for Seroquel. [2010-05-30]. （原始内容存档于2012-03-15）.

[9] Seroquel patent expiration. [2010-05-30]. （原始内容存档于2012-03-15）.

[10] Quepin Full Prescribing Information in Drug Reference Encyclopedia. [2010-04-03]. （原始内容存档于2016-11-07）. .

[11] Riedel M, Müller N, Strassnig M, Spellmann I, Severus E, Möller HJ. Quetiapine in the treatment of schizophrenia and related disorders. Neuropsychiatric Disease and Treatment. April 2007, 3 (2): 219–235. PMC 2654633 . PMID 19300555. doi:10.2147/nedt.2007.3.2.219.

[BNF74-12] British national formulary : BNF 74 74. British Medical Association. 2017: 383. ISBN 978-0857112989.

[13] The Top 300 of 2020. ClinCalc. [7 October 2022]. （原始内容存档于2021-02-12）.

[14] Quetiapine - Drug Usage Statistics. ClinCalc. [7 October 2022]. （原始内容存档于2023-01-05）.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]