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Tiroid peroksidase

Tiroid peroksidase (bahasa Inggris: thyroid iodide peroxidase,[1] thyroid peroxidase, iodide peroxidase, thyroperoxidase, TPO, EC 1.11.1.8) adalah protein yang terglikosilasi dan menempel pada membran plasma apisal tirosit,[2] serta merupakan enzim yang berperan dalam sintesis hormon tiroid[3] termasuk hormon T3, dari residu tiroglobulin,[4] di bawah stimulasi TSH.

TPO membentuk homodimer peka tionamida yang merupakan autoantigen universal pada penyakit Graves dan penyakit autoimunitas lain pada kelenjar tiroid[5] dengan memicu autoantibodi IgG dengan daya ikat tinggi.[6] Pada kasus hipertiroidisme, TPO dihambat oleh 6-propyl-2-thiouracil (PTU) atau 1-methyl-2-mercaptoimidazole (MMI).[1]

Rujukan

  1. ^ a b (Inggris) "Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroid iodine peroxidase". Nagasaka A, Hidaka H. Diakses tanggal 2010-06-19. 
  2. ^ (Inggris) "Development of studies of TPO gene and its application in nuclear medicine". Department of Nuclear Medicine, West China Hospital, Sichuan University; Xing Y, Kuang A. Diakses tanggal 2010-06-19. 
  3. ^ (Inggris) "Structural and functional aspects of thyroid peroxidase". Faculté de Médecine Timone, Université de la Méditerranée; Ruf J, Carayon P. Diakses tanggal 2010-06-19. 
  4. ^ (Inggris) "Distinct immunological and biochemical properties of thyroid peroxidase purified from human thyroid glands and recombinant protein produced in insect cells". Medical Centre of Postgraduate Education, Ul. Marymoncka 99, 01-813, Warsaw; Gardas A, Sutton BJ, Piotrowska U, Pasieka Z, Barnett PS, Huang G, McGregor AM, Banga JP. Diakses tanggal 2010-06-19. 
  5. ^ (Inggris) "Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity". Institute of Human Genetics, Newcastle University; McDonald DO, Pearce SH. Diakses tanggal 2010-06-19. 
  6. ^ (Inggris) "Autoimmune response to the thyroid in humans: thyroid peroxidase--the common autoantigenic denominator". Autoimmune Disease Unit, Cedars-Sinai Research Institute and School of Medicine, University of California; McLachlan SM, Rapoport B. Diakses tanggal 2010-06-19. 


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