21 January – Parliament grants Henry VIII generous tax subsidies.[3]
31 January – Catherine of Aragon miscarries her first child, a daughter, at about six months gestation; told she is still carrying a twin, she prepares for a birth in March–April but there is no child.[4]
February – following Strode's case – that of Member of ParliamentRichard Strode imprisoned by a stannary court due to his attempts to introduce a bill alleviating the harsh conditions of tin miners – Parliament passes an act granting MPs immunity from such prosecutions.[6]
March – Parliament authorises a new poll tax to pay for the War of the League of Cambrai.[3]
16 August – War of the League of Cambrai: Henry VIII leads his troops to victory over French cavalry at the Battle of the Spurs (Second Battle of Guinegate) in Artois.[5]
9 September – War of the League of Cambrai: at the Battle of Flodden, King James IV of Scotland is defeated and killed by an English army under Thomas Howard, Earl of Surrey.[5] Catherine of Aragon learns of this victory while near Buckingham, having ridden north from London to address a speech of encouragement to troops gathering to march to Scotland.
c. 17 September – Catherine of Aragon delivers a son who either miscarries, is stillborn or lives only a few hours.[9]
24 September – War of the League of Cambrai: the city of Tournai surrenders to England.[5]
18 February – Catherine of Aragon gives birth to the King's daughter, who will become queen regnant Mary I of England, at the Palace of Placentia, Greenwich.[15]