This article is about the December 2021 edition of the annual Frisco Bowl. For the one-off bowl game played two days later, see 2021 Frisco Football Classic.
The Roadrunners, from Conference USA (C-USA), finished the regular season with a record of 11–1, 7–1 in conference play. The team won the West Division, advancing to the C-USA Championship Game, defeating Western Kentucky 49–41 for the program's first conference championship. UTSA entered the game ranked no. 24 in the AP Poll and no. 25 in the Coaches Poll. The team was led by second year head coach Jeff Traylor.
The Aztecs, from the Mountain West Conference (MW), finished the regular season with a record of 11–1, 7–1 in conference play. The Aztecs won the West Division and made the MW Championship Game, losing 13–46 to Utah State. The team entered the game ranked no. 24 in the CFP poll. The Aztecs were led by head coach Brady Hoke.