Share to: share facebook share twitter share wa share telegram print page

Bradanicline

Bradanicline
Clinical data
Other namesTC-5619
Identifiers
  • N-[(2S,3R)-2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-2- carboxamide
CAS Number
PubChem CID
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H23N3O2
Molar mass361.445 g·mol−1
3D model (JSmol)
  • C1CN2CCC1[C@@H]([C@@H]2CC3=CN=CC=C3)NC(=O)C4=CC5=CC=CC=C5O4
  (verify)

Bradanicline (INN,[1] code name TC-5619) is a drug which was being developed by Targacept that acts as a partial agonist at the α7 subtype of the neural nicotinic acetylcholine receptors. It showed cognitive enhancing effects in animal studies, and was being developed through a collaboration between Targacept and AstraZeneca as a potential treatment for schizophrenia and attention deficit disorder.[2] Phase I clinical trials were completed successfully, and it was in phase II trials.[3]

In May 2011, AstraZeneca declined to exercise its right to license the compound.[4] In September 2012, Targacept ended its development of badanicline for the purpose of treating ADHD in adults.[5] It was being studied for cognitive and memory enhancement.[6]

Bradanicline was discontinued for Alzheimer's disease and cognitive impairment in schizophrenia in late-2013.[7] It was also discontinued for ADHD.[7]

References

  1. ^ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 73" (PDF). World Health Organization. pp. 68–9. Retrieved 3 January 2017.
  2. ^ "TC-5619 Cognitive Dysfunction in Schizophrenia". Catalyst Biosciences. Archived from the original on August 20, 2008.
  3. ^ Drahl C (September 2008). "Rethinking Schizophrenia". Chemical & Engineering News. 86 (37): 38–40. doi:10.1021/cen-v086n037.p038.
  4. ^ "Targacept retains full development rights for TC-5619". Fierce Biotech. 2 May 2011.
  5. ^ "Targacept ends development of ADHD drug". Market Watch.
  6. ^ "Statement on a Nonproprietary Name Adopted by the USAN Council" (PDF). November 27, 2013.
  7. ^ a b "Bradanicline - Attenua". AdisInsight. Springer Nature Switzerland AG.

Read other articles:

KSME

For the airport serving Somerset, Kentucky assigned the ICAO code KSME, see Lake Cumberland Regional Airport. Radio station in Greeley, ColoradoKSMEGreeley, ColoradoBroadcast areaFort Collins, Colorado Loveland, Colorado Frequency96.1 MHz (HD Radio)Branding96.1 Kiss FMProgrammingFormatFM/HD1:Top 40 HD2: Alternative Radio 94.9OwnershipOwneriHeartMedia(iHM Licenses, LLC)Sister stationsKBPI, KCOL-AM, KIIX, KOLT-FM, KPAW, KXBG, K235BT, K246CI, K297AKHistoryFirst air date1975Former call signsKISF ...

 

Massacre de Douma (2015)

Série de artigos sobre conflitos daGuerra Civil Síria Reações internacionaisRefugiados Revoltas civisBaniyasDaraaHamaHomsJabal al-ZawiyaJisr ash-ShugurLataquiaRastan e TalbisehTalkalakh Insurgências1.ª Ofensiva de Homs1.ª Ofensiva de Idlib (Síria e Turquia  · Massacres de Jabal al-Zawiya  · 1.ª Batalha de Idlib  · Batalha de Saraqeb)Primeira Batalha de RastanConflitos na província de Hama1.ª Ofensiva de Daraa1.ª Ofensiva de Rif Dimashq ...

 

Montgomery County (Iowa)

Montgomery County County in de Verenigde Staten Situering Staat Iowa Coördinaten 41°1'45NB, 95°9'5WL Algemeen Oppervlakte 1.100 km² - land 1.098 km² - water 2 km² Inwoners (2000) 11.771 (11 inw./km²) Overig Zetel Red Oak FIPS-code 19137 Opgericht 1851 Foto's Bevolkingspiramide Montgomery County Statistieken volkstelling Montgomery County Portaal    Verenigde Staten Montgomery County is een county in de Amerikaanse staat Iowa. De county heeft een landoppervlakte van 1.098 km²...

Камаль Бахамдан

كمال باحمدانараб. كمال باحمدان‎ Загальна інформаціяГромадянство  Саудівська АравіяНародження 13 лютого 1970(1970-02-13) (53 роки)Ер-РіадЗріст 172 смВага 69 кгAlma mater Бостонський університетСпортКраїна Саудівська АравіяВид спорту кінний спортДисципліна конкур Участь і здобутк

 

Bouncer's Lane Cemetery, Cheltenham

Bouncer's Lane Cemetery, Cheltenham Bouncer's Lane CemeteryCemetery chapel and crematoriumDetailsEstablished19 November 1864; 159 years ago (19 November 1864)LocationPrestbury, Cheltenham, GloucestershireCountryEnglandCoordinates51°54′24″N 2°02′34″W / 51.906639°N 2.042667°W / 51.906639; -2.042667Owned byCheltenham Borough CouncilSize70 acres (0.28 km2; 0.11 sq mi)WebsiteCemetery groundsFind a GraveBouncer's Lane Cemetery Bouncer'...

 

Goodwill Bridge

Goodwill Bridge Bridge in Queensland, AustraliaGoodwill BridgeGoodwill BridgeCoordinates27°28′50″S 153°01′38″E / 27.480429°S 153.02717°E / -27.480429; 153.02717CarriesPedestrians and cyclistsCrossesBrisbane RiverLocaleBrisbane, Queensland, AustraliaCharacteristicsDesignSteel Through arch bridgeTotal length450 metres (1,480 ft)Width6.5 metres (21 ft)Longest span102 metres (335 ft)Clearance below11.4–12.7 metres (37–42 ft) from high wa...

Hambit Bintih

Artikel biografi ini ditulis menyerupai resume atau daftar riwayat hidup (Curriculum Vitae). Tolong bantu perbaiki agar netral dan ensiklopedis.Drs.Hambit BintihMM[[Bupati Gunung Mas]] 2Masa jabatan2008 – 2013[1]PresidenJend. TNI (Purn.) Dr. H. Susilo Bambang YudhoyonoGubernurAgustin Teras NarangPendahuluDrs. Julius Djudae Anom, M.SiPenggantiDrs. Hardy Rampay, M.Si (Pj.)Wakil Bupati Gunung Mas 1Masa jabatan2003 – 2008PendahuluTidak ada, jabatan baruPengga...

 

Daftar Bupati Kendal

Bupati Kendal Republik IndonesiaHanacaraka : ꧋ꦧꦸꦥꦠꦶꦏꦼꦤ꧀ꦝꦭ꧀Lambang Kabupaten Kendal Moto: Ngesti WiddhiPetahanaDico Ganindutosejak 26 Februari 2021KediamanRumah Dinas Bupati Kabupaten KendalMasa jabatan5 TahunDibentuk28 Juli 1605Pejabat pertamaTumenggung Bahurekso Berikut Adalah Daftar Nama Bupati Kendal dari masa ke masa.       ABRI           GOLKAR    &...

 

Oz the Great and Powerful

2013 fantasy adventure film directed by Sam Raimi Oz the Great and PowerfulTheatrical release posterDirected bySam RaimiScreenplay by Mitchell Kapner David Lindsay-Abaire Story byMitchell KapnerBased onOzby L. Frank BaumProduced byJoe RothStarring James Franco Mila Kunis Rachel Weisz Michelle Williams Zach Braff Bill Cobbs Joey King Tony Cox CinematographyPeter DemingEdited byBob MurawskiMusic byDanny ElfmanProductioncompanies Walt Disney Pictures Roth Films Distributed byWalt Disney StudiosM...

Billy Bevan

Billy Bevan (1920er-Jahre) Billy Bevan (* 29. September 1887 in Orange, New South Wales, Australien; † 26. November 1957 in Escondido, Kalifornien; eigentlich William Bevan Harris) war ein australischer Filmschauspieler und Komiker, der zwischen 1916 und 1950 in über 250 Filmen auftrat. Am bekanntesten ist er für seine zahlreichen stummen Kurzfilme, die er in den 1920er Jahren für Mack Sennett drehte. Inhaltsverzeichnis 1 Leben 2 Filmografie 2.1 Sennett-Kurzfilme (Auswahl) 2.2 Als Neben-...

 

Shake It (album mini)

Shake ItAlbum mini karya SistarDirilisJune 22, 2015Direkam2015GenreK-pop, electropop, dance-popBahasaKoreaLabelStarship EntertainmentKronologi Sistar Sweet & Sour(2014)Sweet & Sour2014 Shake It(2015) Singel dalam album Shake It Shake ItDirilis: 22 Juni 2015 Don't Be Such A Baby (애처럼 굴지마)Dirilis: 25 Juni 2015 Promotional Singles Bad Guy (나쁜놈)Dirilis: 22 Juni 2015 Shake It adalah album mini ketiga dari grup vokal wanita asal Korea Selatan Sistar. Album ini dirilis ...

 

The Scarlet Runner

1916 film The Scarlet RunnerAd for the filmDirected byWilliam P. S. EarleWally VanWritten byGeorge H. PlymptonA. M. WilliamsonC. N. WilliamsonStarringEarle WilliamsMarguerite BlakeDistributed byVitagraph Company of AmericaRelease date October 2, 1916 (1916-10-02) Running time12 episodesCountryUnited StatesLanguageSilent with English intertitles The Scarlet Runner is a 1916 American drama film serial directed by William P. S. Earle and Wally Van. The film is considered lost.[...

11 de noviembre

2023MMXXIII octubre noviembre diciembre sem L M X J V S D 44.ª 30 31 1 2 3 4 5 45.ª 6 7 8 9 10 11 12 46.ª 13 14 15 16 17 18 19 47.ª 20 21 22 23 24 25 26 48.ª 27 28 29 30 1 2 3 [Actualizar calendario]Todos los díasMás calendarios El 11 de noviembre es el 315.º (tricentésimo decimoquinto) día del año en el calendario gregoriano y el 316.º en los años bisiestos. Quedan 50 días para finalizar el año. Acontecimientos 308: en Carnuntum, con el fin de devolver el orden al imperio...

 

Кантемиров, Алибек Тузарович

В Википедии есть статьи о других людях с фамилией Кантемиров. Алибек Кантемиров Дата рождения 16 мая 1882(1882-05-16) Место рождения Терская область, Российская империя Дата смерти 5 июля 1975(1975-07-05) (93 года) Место смерти Орджоникидзе, РСФСР, СССР Гражданство  СССР Подданств�...

 

Live.02

2004 live album by IsisLive.02Live album by IsisReleasedNovember 2004RecordedMarch 19, 2003GenrePost-metal, sludge metal, experimental metalLength65:19LabelSelf-released (CD)Troubleman Unlimited Records (vinyl)(TMU 152)ProducerIsis, Helena Nenne ZetterbergIsis chronology Panopticon(2004) Live.02(2004) Oceanic Remixes(2004) Recorded on March 19, 2003, in Stockholm, Sweden, Live. 02 is Isis's second live release. It is sourced from a Swedish radio recording, and, as such, is the best-so...

Stevens Square, Minneapolis

Neighborhoods of Minneapolis in Hennepin, Minnesota, United StatesStevens Square-Loring HeightsNeighborhoods of MinneapolisStevens Court, the oldest contributing building in the Stevens Square Historic District, built in 1913.Location of Stevens Square/Loring Heights within the U.S. city of MinneapolisCoordinates: 44°57′53″N 93°16′29″W / 44.96472°N 93.27472°W / 44.96472; -93.27472CountryUnited StatesStateMinnesotaCountyHennepinCityMinneapolisCommunityCentra...

 

Bungo Stray Dogs: Dead Apple

2018 animated film by Takuya Igarashi Bungo Stray Dogs: Dead AppleTheatrical release posterDirected byTakuya IgarashiScreenplay byYōji EnokidoBased onBungo Stray Dogsby Kafka AsagiriProduced byJunichirō TamuraChiaki KurakaneStarring Kensho Ono Kishō Taniyama Mamoru Miyano Yūto Uemura Akira Ishida CinematographyTsuyoshi KanbayashiEdited byShigeru NishiyamaMusic byTaku IwasakiProductioncompanyBonesDistributed byKadokawaRelease date March 3, 2018 (2018-03-03) Running time90 mi...

 

Cultural pluralism

Multiple unique cultural identities within a larger society This article is about the concept of cultural pluralism. For other uses of the term, see Pluralism (disambiguation). Part of a series onDiscrimination Forms Institutional Structural Attributes Age Caste Class Dialect Disability Genetic Hair texture Height Language Looks Mental disorder Race / Ethnicity Skin color Scientific racism Rank Sex Sexual orientation Species Size Viewpoint Social Arophobia Acephobia Adultism Anti-alb...

Passion Pit discography

Passion Pit discographyPassion Pit in 2013Studio albums4EPs3Singles14 The discography of Passion Pit, an American indietronica band, has released four studio albums, three extended plays and fourteen singles. Studio albums List of studio albums, with selected chart positions and sales figures Title Album details Peak chart positions Sales US[1] AUS[2] BEL[3] CAN[4] FRA[5] IRE[6] JPN[7] NZ[8] SCO[9] UK[10] Manners ...

 

Stipendiary magistrate

Junior judge in British and other judiciaries This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Stipendiary magistrate – news · newspapers · books · scholar · JSTOR (April 2022) (Learn how and when to remove this template message) Stipendiary magistrates were magistrates that were paid for their work (they rec...

 
Kembali kehalaman sebelumnya