Integrin alpha 2

ITGA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AOX, 1DZI, 1V7P, 4BJ3
Identifiers
Aliases	ITGA2, BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, integrin subunit alpha 2
External IDs	OMIM: 192974; MGI: 96600; HomoloGene: 1662; GeneCards: ITGA2; OMA:ITGA2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	53,094,779 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	115,068,636 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; epithelium of nasopharynx; ; bronchial epithelial cell; ; islet of Langerhans; ; visceral pleura; ; skin of thigh; ; skin of hip; ; gingival epithelium; ; seminal vesicula; ; vulva;
	Top expressed in
	gastrula; ; cumulus cell; ; lumbar spinal ganglion; ; molar; ; blood; ; trigeminal ganglion; ; Paneth cell; ; decidua; ; left lung lobe; ; stellate reticulum;
	More reference expression data
	n/a
Gene ontology
Molecular function	collagen binding; virus receptor activity; protein-containing complex binding; collagen receptor activity; metal ion binding; integrin binding; protein binding; collagen binding involved in cell-matrix adhesion; protein heterodimerization activity; laminin binding; amyloid-beta binding; heparan sulfate proteoglycan binding;
Cellular component	axon terminus; integral component of membrane; cell projection; membrane; focal adhesion; basal part of cell; plasma membrane; cell surface; integrin complex; axon; integrin alpha2-beta1 complex; perinuclear region of cytoplasm; external side of plasma membrane; nucleus;
Biological process	positive regulation of collagen biosynthetic process; positive regulation of inflammatory response; response to hypoxia; positive regulation of phagocytosis, engulfment; skin morphogenesis; response to organic cyclic compound; collagen-activated signaling pathway; positive regulation of leukocyte migration; establishment of protein localization; positive regulation of transmission of nerve impulse; female pregnancy; cellular response to estradiol stimulus; cellular response to organic cyclic compound; hepatocyte differentiation; positive regulation of epithelial cell migration; blood coagulation; extracellular matrix organization; positive regulation of cell projection organization; response to L-ascorbic acid; wound healing; positive regulation of translation; substrate-dependent cell migration; mammary gland development; positive regulation of smooth muscle cell migration; focal adhesion assembly; cell-substrate adhesion; cellular response to mechanical stimulus; cell adhesion; response to parathyroid hormone; cell adhesion mediated by integrin; positive regulation of alkaline phosphatase activity; response to amine; hypotonic response; animal organ morphogenesis; mesodermal cell differentiation; integrin-mediated signaling pathway; positive regulation of collagen binding; viral entry into host cell; positive regulation of DNA binding; cell-matrix adhesion; cell population proliferation; viral process; positive regulation of smooth muscle contraction; response to muscle activity; positive regulation of cell adhesion; positive regulation of smooth muscle cell proliferation; positive regulation of positive chemotaxis; detection of mechanical stimulus involved in sensory perception of pain;
	Sources:Amigo / QuickGO
Orthologs
	3673
	16398
	ENSG00000164171
	ENSMUSG00000015533
	P17301
	Q62469
	NM_002203
	NM_008396
	NP_002194
	NP_032422
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene.

The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface-mediated signalling.^[5]

Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells.^[6]

The DX5 monoclonal antibody recognizes mouse CD49b.^[7]

Interactions

CD49b has been shown to interact with MMP1.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164171 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015533 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)".
^ Gagliani N, Magnani CF, Huber S, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A (2013-06-01). "Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells". Nature Medicine. 19 (6): 739–746. doi:10.1038/nm.3179. ISSN 1546-170X. PMID 23624599. S2CID 21305032.
^ Arase H, Saito T, Phillips JH, Lanier LL (August 2001). "Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)". Journal of Immunology. 167 (3): 1141–4. doi:10.4049/jimmunol.167.3.1141. PMID 11466327.
^ Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA (Aug 2001). "Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction". J. Biol. Chem. 276 (31): 29375–81. doi:10.1074/jbc.M102217200. PMID 11359774.
^ Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC (Aug 2001). "Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. 276 (31): 29368–74. doi:10.1074/jbc.M104179200. PMID 11359786.

External links

CD49b+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
PDBe-KB provides an overview of all the structure information available in the PDB for Human Integrin alpha 2

External links

ITGA2 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
Human ITGA2 genome location and ITGA2 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164171 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015533 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)".

[6] Gagliani N, Magnani CF, Huber S, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A (2013-06-01). "Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells". Nature Medicine. 19 (6): 739–746. doi:10.1038/nm.3179. ISSN 1546-170X. PMID 23624599. S2CID 21305032.

[pmid11466327-7] Arase H, Saito T, Phillips JH, Lanier LL (August 2001). "Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)". Journal of Immunology. 167 (3): 1141–4. doi:10.4049/jimmunol.167.3.1141. PMID 11466327.

[pmid11359774-8] Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA (Aug 2001). "Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction". J. Biol. Chem. 276 (31): 29375–81. doi:10.1074/jbc.M102217200. PMID 11359774.

[pmid11359786-9] Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC (Aug 2001). "Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. 276 (31): 29368–74. doi:10.1074/jbc.M104179200. PMID 11359786.

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Integrin alpha 2

Interactions

References

External links

Further reading

External links