O-2050 is a drug that is a classical cannabinoid derivative, which acts as an antagonist for the CB1receptor. This gives it an advantage in research over many commonly used cannabinoid antagonists, such as rimonabant, which at higher doses act as inverse agonists at CB1 as well as showing off-target effects. However, while O-2050 acts as a silent antagonist in vitro, some tests in vivo have suggested it may show agonist activity under certain circumstances.[1][2][3][4][5][6]
^US 7279500, Martin, Billy R.; Razdan, Raj K. & Pertwee, Roger G, "Sulfonamide cannabinoid agonists and antagonists", published 2007-10-09, assigned to Virginia Commonwealth University
^Gardner A, Mallet PE (January 2006). "Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist'". European Journal of Pharmacology. 530 (1–2): 103–6. doi:10.1016/j.ejphar.2005.11.032. PMID16380113.
^Higuchi S, Ohji M, Araki M, Furuta R, Katsuki M, Yamaguchi R, et al. (January 2011). "Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors". Behavioural Brain Research. 216 (1): 477–80. doi:10.1016/j.bbr.2010.08.042. PMID20817042. S2CID29756189.
