ESRRG

ESRRG
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1KV6, 1TFC, 1VJB, 2E2R, 2EWP, 2GP7, 2GPO, 2GPP, 2GPU, 2GPV, 2P7A, 2P7G, 2P7Z, 2ZAS, 2ZBS, 2ZKC
Identifikatori
Aliasi	ESRRG
Vanjski ID-jevi	OMIM: 602969 MGI: 1347056 HomoloGene: 55581 GeneCards: ESRRG
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	217,137,755 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	187,947,082 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • vezivanje iona cinka; • AF-2 domain binding; • vezivanje iona metala; • steroid hormone receptor activity; • steroid binding; • GO:0001948, GO:0016582 vezivanje za proteine; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity;
Ćelijska komponenta	• nukleoplazma; • jedro;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • retinoic acid receptor signaling pathway; • transcription initiation from RNA polymerase II promoter; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • steroid hormone mediated signaling pathway; • positive regulation of cold-induced thermogenesis;
	Izvori:Amigo / QuickGO
Ortolozi
	2104
	26381
	ENSG00000196482
	ENSMUSG00000026610
	P62508
	P62509
NM_001134285; NM_001243505; NM_001243506; NM_001243507; NM_001243509;
	NM_001243510; NM_001243511; NM_001243512; NM_001243513; NM_001243514; NM_001243515; NM_001243518; NM_001243519; NM_001438; NM_206594; NM_206595; NM_001350122; NM_001350123; NM_001350124; NM_001350125
	NM_001243792; NM_011935; NM_001357534; NM_001357535; NM_001357536
NP_001127757; NP_001230434; NP_001230435; NP_001230436; NP_001230438;
	NP_001230439; NP_001230440; NP_001230441; NP_001230442; NP_001230443; NP_001230444; NP_001230447; NP_001230448; NP_001429; NP_996317; NP_996318; NP_001337051; NP_001337052; NP_001337053; NP_001337054
	NP_001230721; NP_036065; NP_001344463; NP_001344464; NP_001344465
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Estrogenu-srodni receptor gama (ERR-gama), znan i kao NR3B3 (član 3 jedarnih receptora potporodice 3, grupa B), jest protein koji je kod ljudi kodiran genom ESRRG sa hromosoma 1.^[5]^[6]^[7] Ponaša se kao konstitutivni aktivator transkripcije.^[8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 458 aminokiselina, a molekulska težina 51.306 Da.^[9]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MDSVELCLPE	SFSLHYEEEL	LCRMSNKDRH	IDSSCSSFIK	TEPSSPASLT
DSVNHHSPGG	SSDASGSYSS	TMNGHQNGLD	SPPLYPSAPI	LGGSGPVRKL
YDDCSSTIVE	DPQTKCEYML	NSMPKRLCLV	CGDIASGYHY	GVASCEACKA
FFKRTIQGNI	EYSCPATNEC	EITKRRRKSC	QACRFMKCLK	VGMLKEGVRL
DRVRGGRQKY	KRRIDAENSP	YLNPQLVQPA	KKPYNKIVSH	LLVAEPEKIY
AMPDPTVPDS	DIKALTTLCD	LADRELVVII	GWAKHIPGFS	TLSLADQMSL
LQSAWMEILI	LGVVYRSLSF	EDELVYADDY	IMDEDQSKLA	GLLDLNNAIL
QLVKKYKSMK	LEKEEFVTLK	AIALANSDSM	HIEDVEAVQK	LQDVLHEALQ
DYEAGQHMED	PRRAGKMLMT	LPLLRQTSTK	AVQHFYNIKL	EGKVPMHKLF
LEMLEAKV

Funkcija

Ovaj protein je član porodice jedarnih hormonskih receptora, steroidnih hormonskih receptora. Nije poznat fiziološki aktivirajući ligand za ovaj receptor siroče, ali 4-hidroksitamoksifen i dietilstilbestrol djeluju kao inverzni agonisti i deaktiviraju ESRRG.^[10] Također se čini da je meta bisfenola A (vidi dolje).

Vezivanje bisfenola A

Postoje dokazi da bisfenol A funkcioniše kao ksenoestrogen, tako što se snažno vezuje za ERR-γ.^[8] BPA, kao i njegovi nitrirani i hlorirani metaboliti koji se snažno vezuju za ERR-γ (konstanta disocijacije = 5,5 nM), ali ne na estrogeni receptor (ERER).,^[8]^[11] BPA vezivanje za ERR-γ čuva njegovu baznu konstitutivnu aktivnost.^[8] Također ga može zaštititi od deaktivacije selektivnog modulatora estrogenih receptora 4-hidroksitamoksifena.^[8]

Različita ekspresija ERR-γ u različitim dijelovima tijela može objasniti varijacije u efektima bisfenola A. Naprimjer, ERR-γ pronađen je u visokoj koncentraciji u placenti, što objašnjava izvještaje o visokoj akumulaciji bisfenola A u njoj.^[12]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196482 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026610 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ESRRG estrogen-related receptor gamma".
^ Eudy JD, Yao S, Weston MD, Ma-Edmonds M, Talmadge CB, Cheng JJ, Kimberling WJ, Sumegi J (Jun 1998). "Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of Usher syndrome type IIa at 1q41". Genomics. 50 (3): 382–4. doi:10.1006/geno.1998.5345. PMID 9676434.
^ Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT (Mar 1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR". Gene. 228 (1–2): 101–9. doi:10.1016/S0378-1119(98)00619-2. PMID 10072763.
^ ^a ^b ^c ^d ^e Matsushima A, Kakuta Y, Teramoto T, Koshiba T, Liu X, Okada H, Tokunaga T, Kawabata S, Kimura M, Shimohigashi Y (Oct 2007). "Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma". Journal of Biochemistry. 142 (4): 517–24. doi:10.1093/jb/mvm158. PMID 17761695.
^ "UniProt, P62508" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ Huppunen J, Aarnisalo P (Feb 2004). "Dimerization modulates the activity of the orphan nuclear receptor ERRgamma". Biochemical and Biophysical Research Communications. 314 (4): 964–70. doi:10.1016/j.bbrc.2003.12.194. PMID 14751226.
^ Babu S, Vellore NA, Kasibotla AV, Dwayne HJ, Stubblefield MA, Uppu RM (Sep 2012). "Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma". Biochemical and Biophysical Research Communications. 426 (2): 215–20. doi:10.1016/j.bbrc.2012.08.065. PMID 22935422.
^ Takeda Y, Liu X, Sumiyoshi M, Matsushima A, Shimohigashi M, Shimohigashi Y (Jul 2009). "Placenta expressing the greatest quantity of bisphenol A receptor ERR{gamma} among the human reproductive tissues: Predominant expression of type-1 ERRgamma isoform". Journal of Biochemistry. 146 (1): 113–22. doi:10.1093/jb/mvp049. PMID 19304792.

Dopunska literatura

Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Hong H, Yang L, Stallcup MR (Aug 1999). "Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3". The Journal of Biological Chemistry. 274 (32): 22618–26. doi:10.1074/jbc.274.32.22618. PMID 10428842.
Heard DJ, Norby PL, Holloway J, Vissing H (Mar 2000). "Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult". Molecular Endocrinology. 14 (3): 382–92. doi:10.1210/me.14.3.382. PMID 10707956.
Greschik H, Wurtz JM, Sanglier S, Bourguet W, van Dorsselaer A, Moras D, Renaud JP (Feb 2002). "Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3". Molecular Cell. 9 (2): 303–13. doi:10.1016/S1097-2765(02)00444-6. PMID 11864604.
Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
Hentschke M, Süsens U, Borgmeyer U (Aug 2002). "Domains of ERRgamma that mediate homodimerization and interaction with factors stimulating DNA binding". European Journal of Biochemistry. 269 (16): 4086–97. doi:10.1046/j.1432-1033.2002.03102.x. PMID 12180985.
Hentschke M, Süsens U, Borgmeyer U (Dec 2002). "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma". Biochemical and Biophysical Research Communications. 299 (5): 872–9. doi:10.1016/S0006-291X(02)02753-5. PMID 12470660.
Hentschke M, Schulze C, Süsens U, Borgmeyer U (Mar 2003). "Characterization of calmodulin binding to the orphan nuclear receptor Errgamma". Biological Chemistry. 384 (3): 473–82. doi:10.1515/BC.2003.053. PMID 12715898. S2CID 41163978.
Hentschke M, Borgmeyer U (Dec 2003). "Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma". Biochemical and Biophysical Research Communications. 312 (4): 975–82. doi:10.1016/j.bbrc.2003.11.025. PMID 14651967.
Cheung CP, Yu S, Wong KB, Chan LW, Lai FM, Wang X, Suetsugi M, Chen S, Chan FL (Mar 2005). "Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues". The Journal of Clinical Endocrinology and Metabolism. 90 (3): 1830–44. doi:10.1210/jc.2004-1421. PMID 15598686.
Liu D, Zhang Z, Teng CT (Apr 2005). "Estrogen-related receptor-gamma and peroxisome proliferator-activated receptor-gamma coactivator-1alpha regulate estrogen-related receptor-alpha gene expression via a conserved multi-hormone response element". Journal of Molecular Endocrinology. 34 (2): 473–87. doi:10.1677/jme.1.01586. PMID 15821111.
Gao M, Sun P, Wang J, Zhao D, Wei L (2006). "Expression of estrogen receptor-related receptor isoforms and clinical significance in endometrial adenocarcinoma". International Journal of Gynecological Cancer. 16 (2): 827–33. doi:10.1111/j.1525-1438.2006.00527.x. PMID 16681769. S2CID 37213476.
Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT (Dec 2006). "X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation". The Journal of Biological Chemistry. 281 (49): 37773–81. doi:10.1074/jbc.M608410200. PMID 16990259.
Babu S, Vellore NA, Kasibotla AV, Dwayne HJ, Stubblefield MA, Uppu RM (Sep 2012). "Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma". Biochemical and Biophysical Research Communications. 426 (2): 215–20. doi:10.1016/j.bbrc.2012.08.065. PMID 22935422.

Vanjski linkovi

"Master protein found to enhance both muscles and the brain". KurzweilAI. 7. 4. 2015. Pristupljeno mart 2015. Provjerite vrijednost datuma u parametru: |access-date= (pomoć)

Šablon:Modulatori estrogen-srodnih receptora

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196482 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026610 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ESRRG estrogen-related receptor gamma".

[pmid9676434-6] Eudy JD, Yao S, Weston MD, Ma-Edmonds M, Talmadge CB, Cheng JJ, Kimberling WJ, Sumegi J (Jun 1998). "Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of Usher syndrome type IIa at 1q41". Genomics. 50 (3): 382–4. doi:10.1006/geno.1998.5345. PMID 9676434.

[pmid10072763-7] Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT (Mar 1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR". Gene. 228 (1–2): 101–9. doi:10.1016/S0378-1119(98)00619-2. PMID 10072763.

[matsushima-8] Matsushima A, Kakuta Y, Teramoto T, Koshiba T, Liu X, Okada H, Tokunaga T, Kawabata S, Kimura M, Shimohigashi Y (Oct 2007). "Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma". Journal of Biochemistry. 142 (4): 517–24. doi:10.1093/jb/mvm158. PMID 17761695.

[UniProt-9] "UniProt, P62508" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[pmid14751226-10] Huppunen J, Aarnisalo P (Feb 2004). "Dimerization modulates the activity of the orphan nuclear receptor ERRgamma". Biochemical and Biophysical Research Communications. 314 (4): 964–70. doi:10.1016/j.bbrc.2003.12.194. PMID 14751226.

[babu-11] Babu S, Vellore NA, Kasibotla AV, Dwayne HJ, Stubblefield MA, Uppu RM (Sep 2012). "Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma". Biochemical and Biophysical Research Communications. 426 (2): 215–20. doi:10.1016/j.bbrc.2012.08.065. PMID 22935422.

[pmid19304792-12] Takeda Y, Liu X, Sumiyoshi M, Matsushima A, Shimohigashi M, Shimohigashi Y (Jul 2009). "Placenta expressing the greatest quantity of bisphenol A receptor ERR{gamma} among the human reproductive tissues: Predominant expression of type-1 ERRgamma isoform". Journal of Biochemistry. 146 (1): 113–22. doi:10.1093/jb/mvp049. PMID 19304792.

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