STEAP4

STEAP4
Identifikatori
Aliasi	STEAP4
Vanjski ID-jevi	OMIM: 611098 MGI: 1923560 HomoloGene: 36422 GeneCards: STEAP4
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	88,306,894 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	8,032,213 bp
Ontologija gena
Molekularna funkcija	• oxidoreductase activity; • ferric-chelate reductase (NADPH) activity; • vezivanje iona metala; • cupric reductase activity; • electron transfer activity; • heme binding; • FAD binding;
Ćelijska komponenta	• integral component of membrane; • Golđijeva membrana; • ćelijska membrana; • Egzosom; • membrana; • endozom; • integral component of plasma membrane; • Golđijev aparat; • early endosome membrane;
Biološki proces	• iron ion homeostasis; • copper ion import; • ion transport; • fat cell differentiation; • iron ion import across cell outer membrane; • GO:0015915 transport; • Lanac transporta elektrona; • protein homotrimerization;
	Izvori:Amigo / QuickGO
Ortolozi
	79689
	117167
	ENSG00000127954
	ENSMUSG00000012428
	Q687X5
	Q923B6
	NM_024636; NM_001205315; NM_001205316
	NM_054098
	NP_001192244; NP_001192245; NP_078912
	NP_473439
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 4 porodice STEAP jest protein koji je kod ljudi kodiran genom STEAP4.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 459 aminokiselina, а molekulska težina 51.981 Da.^[6].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEKTCIDALP	LTMNSSEKQE	TVCIFGTGDF	GRSLGLKMLQ	CGYSVVFGSR
NPQKTTLLPS	GAEVLSYSEA	AKKSGIIIIA	IHREHYDFLT	ELTEVLNGKI
LVDISNNLKI	NQYPESNAEY	LAHLVPGAHV	VKAFNTISAW	ALQSGALDAS
RQVFVCGNDS	KAKQRVMDIV	RNLGLTPMDQ	GSLMAAKEIE	KYPLQLFPMW
RFPFYLSAVL	CVFLFFYCVI	RDVIYPYVYE	KKDNTFRMAI	SIPNRIFPIT
ALTLLALVYL	PGVIAAILQL	YRGTKYRRFP	DWLDHWMLCR	KQLGLVALGF
AFLHVLYTLV	IPIRYYVRWR	LGNLTVTQAI	LKKENPFSTS	SAWLSDSYVA
LGILGFFLFV	LLGITSLPSV	SNAVNWREFR	FVQSKLGYLT	LILCTAHTLV
YGGKRFLSPS	NLRWYLPAAY	VLGLIIPCTV	LVIKFVLIMP	CVDNTLTRIR
QGWERNSKH

Funkcija

Protein kodiran ovim genom pripada porodici STEAP (eng. skr. od šestotransmembranski epitelni antigen prostate), a nalazi se u Golgijevom aparatu. Funkcionira kao metaloreduktaza koja ima sposobnost redukcije i Fe (3+) na Fe (2+) i Cu (2+) na Cu (1+), koristeći NAD (+) kao akceptor. Studije na miševima i ljudima ukazuju da ovaj gen može biti uključen u razvoj adipocita i metabolizam, te može pridonijeti normalnoj biologiji ćelija prostate, kao i progresiji kancera. Za ovaj gen pronađene su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127954 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000012428 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: STEAP family member 4".
^ "UniProt, Q687X5" (jezik: engleski). Pristupljeno 29. 9. 2021.

Dopunska literatura

Zhang CM, Chi X, Wang B, Zhang M, Ni YH, Chen RH, Li XN, Guo XR (maj 2008). "Downregulation of STEAP4, a highly-expressed TNF-alpha-inducible gene in adipose tissue, is associated with obesity in humans". Acta Pharmacologica Sinica. 29 (5): 587–92. doi:10.1111/j.1745-7254.2008.00793.x. PMID 18430367. S2CID 20248700.
Bi YW, Wang CM, Yan ZT, Li NF, Guo YY, Wang HM, Yao XG, Liang DP (februar 2011). "[Negative association of STAMP2 gene polymorphisms with essential hypertension in Xinjiang Uygur population]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. 28 (1): 64–8. doi:10.3760/cma.j.issn.1003-9406.2011.01.015. PMID 21287513.
Kralisch S, Sommer G, Weise S, Lipfert J, Lossner U, Kamprad M, Schröck K, Bluher M, Stumvoll M, Fasshauer M (april 2009). "Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro". FEBS Letters. 583 (7): 1196–200. doi:10.1016/j.febslet.2009.03.015. PMID 19289123. S2CID 31106264.
Guo YY, Li NF, Wang CM, Yan ZT, Zhang JH, Wang HM, Zhou L, Luo WL (februar 2011). "[Genetic variation and association of STEAP4 gene with metabolic syndrome in Chinese Uygur patients]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. 28 (1): 78–82. doi:10.3760/cma.j.issn.1003-9406.2011.01.018. PMID 21287516.
Nanfang L, Yanying G, Hongmei W, Zhitao Y, Juhong Z, Ling Z, Wenli L (august 2010). "Variations of six transmembrane epithelial antigen of prostate 4 (STEAP4) gene are associated with metabolic syndrome in a female Uygur general population". Archives of Medical Research. 41 (6): 449–56. doi:10.1016/j.arcmed.2010.08.006. PMID 21044749.
Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Umeda N, Kanamori A, Ochiai N, Miyazawa K, Sugihara M, Hayashi T, Goto D, Ito S, Sumida T (februar 2012). "Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis". Modern Rheumatology. 22 (1): 128–36. doi:10.1007/s10165-011-0475-y. PMID 21633911. S2CID 21108512.
Guo YY, Li NF, Zhou L, Yao XG, Wang HM, Zhang JH, Luo WL (juli 2011). "A common variation within the STEAP4 gene exons is associated with obesity in Uygur general population". Chinese Medical Journal. 124 (14): 2096–100. PMID 21933608.
Wangensteen T, Akselsen H, Holmen J, Undlien D, Retterstøl L (mart 2011). "A common haplotype in NAPEPLD is associated with severe obesity in a Norwegian population-based cohort (the HUNT study)". Obesity. 19 (3): 612–7. doi:10.1038/oby.2010.219. PMID 20885390. S2CID 205528202.
Korkmaz CG, Korkmaz KS, Kurys P, Elbi C, Wang L, Klokk TI, Hammarstrom C, Troen G, Svindland A, Hager GL, Saatcioglu F (juli 2005). "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer". Oncogene. 24 (31): 4934–45. doi:10.1038/sj.onc.1208677. PMID 15897894. S2CID 22999842.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127954 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000012428 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: STEAP family member 4".

[UniProt-6] "UniProt, Q687X5" (jezik: engleski). Pristupljeno 29. 9. 2021.

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