CCL1

CCL1
[[Datei:|250x200px|CCL1]]
CCL1
Andere Namen
  • Chemokine (C-C Motif) Ligand 1
  • T Lymphocyte-Secreted Protein I-309
  • SCYA1
  • Small Inducible Cytokine A1 (I-309, Homologous To Mouse Tca-3)
  • Inflammatory Cytokine I-309
  • I-309
  • P500
  • SISe
  • TCA3

Vorhandene Strukturdaten: 1EL0, 4OIJ, 4OIK

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 96 Aminosäuren, 10992 Da
Bezeichner
Gen-Namen CCL1, P500, SISe, TCA3, I-309, SCYA1
Externe IDs
Vorkommen
Homologie-Familie Hovergen
Orthologe
Mensch Hausmaus
Entrez 6346 20290
Ensembl ENSG00000108702 ENSMUSG00000020702
UniProt P22362 P10146
Refseq (mRNA) NM_002981 NM_011329
Refseq (Protein) NP_002972 NP_035459
Genlocus Chr 17: 34.36 – 34.36 Mb Chr 11: 82.18 – 82.18 Mb
PubMed-Suche 6346 20290

CCL1 (englisch CC-chemokine ligand 1) ist ein Zytokin aus der Familie der CC-Chemokine.

Eigenschaften

CCL1 ist an Entzündungsprozessen beteiligt.[1] Es bindet an CCR8 und ist chemotaktisch für verschiedene Immunzellen, darunter Monozyten, NK-Zellen, unreife B-Zellen und dendritische Zellen.[2]

Einzelnachweise

  1. ↑ Miller MD, Krangel MS: The human cytokine I-309 is a monocyte chemoattractant. In: Proc. Natl. Acad. Sci. U.S.A. 89. Jahrgang, Nr. 7, April 1992, S. 2950–4, doi:10.1073/pnas.89.7.2950, PMID 1557400, PMC 48781 (freier Volltext) – (englisch).
  2. ↑ Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B: Identification of CCR8, the receptor for the human CC chemokine I-309. In: J. Biol. Chem. 272. Jahrgang, Nr. 28, Juli 1997, S. 17251–4, doi:10.1074/jbc.272.28.17251, PMID 9211859 (englisch).

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