CCL14

Vorhandene Strukturdaten: 2Q8R, 2Q8T

CCL14
Andere Namen
  • Chemokine (C-C Motif) Ligand 14
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 14
  • Chemokine CC-1/CC-3
  • HCC-1(1-74)
  • Hemofiltrate CC Chemokine 1

Vorhandene Strukturdaten: 2Q8R, 2Q8T

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 93 Aminosäuren, 10.678 Da (Isoform 1)

109 Aminosäuren, 12.297 Da (Isoform 2)

Isoformen 2
Bezeichner
Gen-Namen CCL14, SCYA14, NCC2, HCC-3, CKB1, MCIF, SY14
Externe IDs
Vorkommen
Homologie-Familie Hovergen
Orthologe (Mensch)
Entrez 6358
Ensembl ENSG00000276409
UniProt Q16627
Refseq (mRNA) NM_032962
Refseq (Protein) NP_116738
Genlocus Chr 17: 35.98 – 35.99 Mb
PubMed-Suche 6358

CCL14 (englisch CC-chemokine ligand 14, synonym HCC-1) ist ein Zytokin aus der Familie der CC-Chemokine.

Eigenschaften

CCL14 ist ein Präprotein und wird in eine aktive Form von 76 Aminosäuren gespalten. Die aktive Form ist an Entzündungsprozessen beteiligt. CCL14 besitzt eine hohe Homologie zu CCL3 und CCL4. Es aktiviert Monozyten. CCL14 wird in der Milz, im Knochenmark, in der Leber, in Muskeln und im Darm gebildet.[1]

Einzelnachweise

  1. ↑ Schulz-Knappe et al., HCC-1, a novel chemokine from human plasma. J. Exp. Med., 1996, 183: 295-299.

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