CCL15

CCL15
[[Datei:|250x200px|CCL15]]
nach PDB 2HCC
CCL15
Andere Namen
  • Chemokine (C-C Motif) Ligand 15
  • Macrophage Inflammatory Protein 5
  • Chemokine CC-2
  • MIP-1 Delta
  • SCYA15
  • NCC3
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 15
  • Leukotactin 1
  • MRP-2B
  • HCC-2
  • LKN-1
  • MIP-5
  • HMRP-2B
  • SY15

Vorhandene Strukturdaten: 2HCC

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 113 Aminosäuren, 12248 Da
Bezeichner
Externe IDs
Vorkommen
Homologie-Familie Hovergen

CCL15 (englisch CC-chemokine ligand 15) ist ein Zytokin aus der Familie der CC-Chemokine.

Eigenschaften

CCL15 ist an Entzündungsprozessen beteiligt. Es ist chemotaktisch für und aktiviert verschiedene Immunzellen, darunter Neutrophile, Monozyten und T-Zellen. CCL15 wird in der Leber, im Darm und in Leukozyten und Makrophagen der Lunge gebildet.[1] CCL15 bindet an CCR1 und CCR3.[2][3]

Einzelnachweise

  1. ↑ Pardigol et al. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Proc. Nat. Acad. Sci. 95: 6308-6313, 1998.
  2. ↑ Youn et al. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immun. 159: 5201-5205, 1997.
  3. ↑ Coulin et al. Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines. Europ. J. Biochem. 248: 507-515, 1997.

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