CCL16

CCL16 (englisch CC-chemokine ligand 16) ist ein Zytokin aus der Familie der CC-Chemokine.

CCL16
Andere Namen
  • Chemokine (C-C Motif) Ligand 16
  • SCYA16
  • NCC4
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 16
  • Lymphocyte And Monocyte Chemoattractant
  • Liver-Expressed Chemokine
  • IL-10-Inducible Chemokine
  • Chemokine LEC
  • Monotactin-1
  • ILINCK
  • HCC-4
  • Mtn-1
  • LCC-1
  • CKb12
  • SCYL4
  • LEC
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 120 Aminosäuren, 13600 Da
Bezeichner
Externe IDs
Vorkommen
Homologie-Familie Hovergen

CCL16 (englisch CC-chemokine ligand 16) ist ein Zytokin aus der Familie der CC-Chemokine.

Eigenschaften

CCL8 ist an Entzündungsprozessen beteiligt. Es ist chemotaktisch für und aktiviert verschiedene Immunzellen, darunter Monozyten und T-Lymphozyten. CCL16 wird in der Leber, dem Thymus und der Milz gebildet.[1] CCL16 wird in Monozyten durch IL-10, IFN-γ und bakterielle Lipopolysaccharide induziert. CCL16 bindet an CCR1, CCR2, CCR5 und CCR8.[2][3]

Einzelnachweise

  1. ↑ Youn et al. Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. Biochem. Biophys. Res. Commun. 247:217-222 (1998).
  2. ↑ Nomiyama et al. Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes. Int Immunol. 2001 Aug;13(8):1021-9.
  3. ↑ Howard et al. LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8. Blood. 2000 Aug 1;96(3):840-5.

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