CCL20

Chemokine (C-C Motif) Ligand 20; SCYA20; MIP3A; LARC; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 20; Liver And Activation-Regulated Chemokine; Macro…

CCL20
CCL20
CCL20
nach PDB 1M8A
Andere Namen

Chemokine (C-C Motif) Ligand 20; SCYA20; MIP3A; LARC; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 20; Liver And Activation-Regulated Chemokine; Macrophage Inflammatory Protein 3 Alpha; Small-Inducible Cytokine A20; CC Chemokine LARC; MIP-3-Alpha; Beta Chemokine Exodus-1; Beta-Chemokine Exodus-1; C-C Motif Chemokine 20; Exodus; MIP-3a; CKb4; ST38

Vorhandene Strukturdaten: 1M8A, 2HCI, 2JYO

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 96 Aminosäuren, 10762 Da
Bezeichner
Externe IDs
Vorkommen
Homologie-Familie Hovergen
Orthologe
Mensch Hausmaus
Entrez 6364 20297
UniProt P78556 O89093
PubMed-Suche 6364 20297

CCL20 (englisch CC-chemokine ligand 20) ist ein Zytokin aus der Familie der CC-Chemokine.

Eigenschaften

CCL20 ist an Entzündungsprozessen beteiligt. Es ist chemotaktisch für Lymphozyten und in geringerem Umfang auch für Neutrophiles.[1] CCL20 bindet an den Rezeptor CCR6.[2] CCL20 wird durch Lipopolysaccharide (LPS) oder die Zytokine TNF-alpha und Interferon-γ induziert und durch IL-10 herabreguliert.[3] CCL20 wird gebildet von Lymphozyten, in Lymphknoten, in der Leber, im Wurmfortsatz, in der fetalen Lunge und in geringerem Umfang im Thymus, den Hoden und dem Darm.[1][4]

Einzelnachweise

  1. ↑ a b Hieshima K, Imai T, Opdenakker G, Van Damme J, Kusuda J, Tei H, Sakaki Y, Takatsuki K, Miura R, Yoshie O, Nomiyama H: Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. In: J. Biol. Chem. 272. Jahrgang, Nr. 9, 1997, S. 5846–5853, doi:10.1074/jbc.272.9.5846, PMID 9038201 (englisch).
  2. ↑ Baba M, Imai T, Nishimura M, Kakizaki M, Takagi S, Hieshima K, Nomiyama H, Yoshie O: Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. In: J. Biol. Chem. 272. Jahrgang, Nr. 23, 1997, S. 14893–14898, doi:10.1074/jbc.272.23.14893, PMID 9169459 (englisch).
  3. ↑ Schutyser E, Struyf S, Menten P, Lenaerts JP, Conings R, Put W, Wuyts A, Proost P, Van Damme J: Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells. In: J. Immunol. 165. Jahrgang, Nr. 8, 2000, S. 4470–7, doi:10.4049/jimmunol.165.8.4470, PMID 11035086 (englisch, jimmunol.org).
  4. ↑ Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A: Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta. In: J. Immunol. 158. Jahrgang, Nr. 3, 1997, S. 1033–6, PMID 9013939 (englisch, jimmunol.org).

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