CCL24

Vorhandene Strukturdaten: 1EIG, 1EIH

CCL24
Andere Namen
  • Chemokine (C-C Motif) Ligand 24
  • Myeloid Progenitor Inhibitory Factor 2
  • CK-Beta-6
  • Eotaxin-2
  • SCYA24
  • MPIF2
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 24
  • Eosinophil Chemotactic Protein 2
  • Ckb-6

Vorhandene Strukturdaten: 1EIG, 1EIH

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 119 Aminosäuren, 13134 Da
Bezeichner
Externe IDs
Vorkommen
Homologie-Familie Hovergen
Orthologe
Mensch Hausmaus
Entrez 6369 56221
UniProt O00175 Q9JKC0
PubMed-Suche 6369 56221

CCL24 (englisch CC-chemokine ligand 24) ist ein Zytokin aus der Familie der CC-Chemokine.

Eigenschaften

CCL24 ist an Entzündungsprozessen beteiligt. Es bindet an CCR3 und ist chemotaktisch für Eosinophile,[1] ruhende T-Zellen und in geringerem Umfang auch für Neutrophile.[2] CCL24 ist an der Entstehung von Acetylsalicylsäure-induziertem Asthma beteiligt.[3]

Einzelnachweise

  1. ↑ White JR, Imburgia C, Dul E, Appelbaum E, O’Donnell K, O’Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM: Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. In: J. Leukoc. Biol. 62. Jahrgang, Nr. 5, November 1997, S. 667–75, PMID 9365122 (englisch).
  2. ↑ Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G: Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. In: J. Exp. Med. 185. Jahrgang, Nr. 7, April 1997, S. 1163–72, doi:10.1084/jem.185.7.1163, PMID 9104803, PMC 2196270 (freier Volltext) – (englisch).
  3. ↑ Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS: Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease. In: Allergy. 65. Jahrgang, Nr. 3, Oktober 2009, S. 338–346, doi:10.1111/j.1398-9995.2009.02158.x, PMID 19796209 (englisch).

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