CCL25

CCL25

CCL25
Andere Namen
  • Chemokine (C-C Motif) Ligand 25
  • SCYA25
  • TECK
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 25
  • Thymus Expressed Chemokine
  • Ck Beta-15
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 150 Aminosäuren, 16609 Da
Bezeichner
Externe IDs
Vorkommen
Homologie-Familie Hovergen
Orthologe
Mensch Hausmaus
Entrez 6370 20300
UniProt O15444 O35903
PubMed-Suche 6370 20300

CCL25 (englisch CC-chemokine ligand 25) ist ein Zytokin aus der Familie der CC-Chemokine.

Eigenschaften

CCL25 ist an Entzündungsprozessen und an der Entwicklung von T-Zellen beteiligt.[1] CCL25 bindet an den Rezeptor CCR9, der von Thymocyten, Makrophagen und dendritischen Zellen gebildet wird.[2][3]

Einzelnachweise

  1. ↑ A. P. Vicari, D. J. Figueroa, J. A. Hedrick, J. S. Foster, K. P. Singh, S. Menon, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, K. B. Bacon, A. Zlotnik: TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. In: Immunity. Band 7, Nummer 2, August 1997, S. 291–301, PMID 9285413.
  2. ↑ A. Zaballos, J. Gutiérrez, R. Varona, C. Ardavín, G. Márquez: Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. In: Journal of Immunology. Band 162, Nummer 10, Mai 1999, S. 5671–5675, PMID 10229797.
  3. ↑ Gosling et al., Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J Immunol. 2000, 164:2851-6.

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