CCL7

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CCL7
CCL7
nach PDB 1BO0
CCL7
Andere Namen
  • Chemokine (C-C Motif) Ligand 7
  • Monocyte Chemoattractant Protein 3
  • SCYA7
  • MCP3
  • Small Inducible Cytokine A7 (Monocyte Chemotactic Protein 3)
  • SCYA6
  • NC28
  • MARC
  • FIC

Vorhandene Strukturdaten: 1BO0, 1NCV

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 99 Aminosäuren, 11200 Da
Bezeichner
Externe IDs
Vorkommen
Homologie-Familie Hovergen

CCL7 (englisch CC-chemokine ligand 7) ist ein Zytokin aus der Familie der CC-Chemokine.

Eigenschaften

CCL7 ist an Entzündungsprozessen beteiligt.[1] Es wird von Monozyten und manchen Tumorzelllinien gebildet.[2] Die größte Homologie besitzen CCL7 und CCL2 (synonym MCP1). CCL7 bindet an die Matrix-Metalloprotease MMP2.[3]

Einzelnachweise

  1. ↑ Opdenakker G, Fiten P, Nys G, Froyen G, Van Roy N, Speleman F, Laureys G, Van Damme J: The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12. In: Genomics. 21. Jahrgang, Nr. 2, 1994, S. 403–8, doi:10.1006/geno.1994.1283, PMID 7916328 (englisch).
  2. ↑ Opdenakker G, Froyen G, Fiten P, Proost P, Van Damme J: Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. In: Biochem. Biophys. Res. Commun. 191. Jahrgang, Nr. 2, 1993, S. 535–42, doi:10.1006/bbrc.1993.1251, PMID 8461011 (englisch).
  3. ↑ G. A. McQuibban, J. H. Gong. E.M. Tam, C. A. McCulloch, I. Clark-Lewis, C. M. Overall: Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. In: Science. 289. Jahrgang, Nr. 5482. UNITED STATES August 2000, S. 1202–6, doi:10.1126/science.289.5482.1202, PMID 10947989 (englisch).

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