CXCL2

Growth-regulated protein beta, Gro-beta

CXCL2
C-X-C motif chemokine 2
C-X-C motif chemokine 2
nach PDB 1QNK
Andere Namen

Growth-regulated protein beta, Gro-beta

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 107 Aminosäuren, 11.389 Da
Bezeichner
Externe IDs
Vorkommen
Homologie-Familie Hovergen

C-X-C motif chemokine 2 (CXCL2) ist ein Protein aus der Gruppe der Chemokine.

Eigenschaften

CXCL2 wird von aktivierten Monozyten, Makrophagen und Neutrophilen am Ort einer Entzündung gebildet und rekrutiert polymorphkernige Leukozyten und hämatopoetische Stammzellen.[1][2][3] Die Aminosäuren 5 bis 73 zeigen eine chemoattraktive Wirkung auf Neutrophile. CXCL2 besitzt zwei Disulfidbrücken. CXCL2 bindet an CXCR1 und CXCR2.[3] Es wird als Reaktion auf Lipopolysaccharide gebildet. Es ist zu 90 % identisch zu CXCL1. Beim Menschen liegt das Gen auf Chromosom 4 in einem Gen-Cluster mit anderen CXC-Chemokinen.[4]

Einzelnachweise

  1. ↑ Wolpe, S. D., Sherry, B., Juers, D., Davatelis, G., Yurt, R. W., Cerami, A. Identification and characterization of macrophage inflammatory protein 2. Proc. Natl. Acad. Sci. 86: 612-616, 1989. PMID 2643119
  2. ↑ Iida N., Grotendorst G.R. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol. Cell. Biol. 10:5596-5599, 1990. PMID 2078213
  3. ↑ a b Pelus LM, Fukuda S. Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties. Exp Hematol. 2006 Aug;34(8):1010-20. PMID 16863907
  4. ↑ O’Donovan, N., Galvin, M., Morgan, J. G. Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84: 39-42, 1999. PMID 10343098

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