Calpinactam
fest[1]
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| Allgemeines | |||||||||||||
| Name | Calpinactam | ||||||||||||
| Summenformel | C38H57N9O8 | ||||||||||||
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| Eigenschaften | |||||||||||||
| Molare Masse | 767,93 g·mol−1 | ||||||||||||
| Aggregatzustand |
fest[1] | ||||||||||||
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| Wenn nicht anders vermerkt, gelten die angegebenen Daten bei Standardbedingungen (0 °C, 1000 hPa). | |||||||||||||
Calpinactam ist ein Antibiotikum, das 2009 aus dem Pilz Mortierella alpina von einer Gruppe um den Japaner Hiroshi Tomoda (* 1955)[2] isoliert wurde.[3][4] Das Besondere an diesem Hexapeptid ist, dass der C-Terminus von α-Amino-ε-caprolactam gebildet wird, das aus Lysin gewonnen werden kann. Wirksam ist es in vitro gegen die Bakterienarten Mycobacterium smegmatis und Mycobacterium tuberculosis. 2012 gelang der Gruppe von Tomoda auch die Synthese von Calpinactam.[5]
Einzelnachweise
- ↑ a b c Datenblatt Calpinactam bei Santa Cruz Biotechnology, abgerufen am 16. Januar 2023.
- ↑ Hiroshi Tomoda. In: Prabook. Abgerufen am 16. Januar 2023 (englisch).
- ↑ Nobuhiro Koyama, Shigenobu Kojima, Takeo Fukuda, Tohru Nagamitsu, Tadashi Yasuhara, Satoshi O̅mura, Hiroshi Tomoda: Structure and Total Synthesis of Fungal Calpinactam, A New Antimycobacterial Agent. In: Organic Letters. 12, 2010, S. 432–435, doi:10.1021/ol902553z.
- ↑ N. Koyama, S. Kojima, K. Nonaka, R. Masuma, M. Matsumoto, S. Omura, H. Tomoda: Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905. In: The Journal of Antibiotics. Band 63, Nummer 4, April 2010, S. 183–186, doi:10.1038/ja.2010.14, PMID 20186169.
- ↑ Kenichiro Nagai, Nobuhiro Koyama, Noriko Sato, Chisato Yanagisawa, Hiroshi Tomoda: Synthesis and antimycobacterial activity of calpinactam derivatives. In: Bioorganic & Medicinal Chemistry Letters. 22, 2012, S. 7739–7741, doi:10.1016/j.bmcl.2012.09.069.
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