Concatamer

Ein Concatamer (synonym Concatemer) ist ein Biopolymer mit einer Serie von Wiederholungseinheiten, z. B. repetitive DNA (synonym tandem repeat DNA) oder Protein…

Ein Concatamer (synonym Concatemer) ist ein Biopolymer mit einer Serie von Wiederholungseinheiten, z. B. repetitive DNA (synonym tandem repeat DNA) oder Proteine mit repetitiven Aminosäuresequenzen.[1]

Eigenschaften

Concatamere bilden eine typische Zwischenstufe bei der rolling circle replication. Einige Viren (insbesondere Bakteriophagen) produzieren im Verlauf ihrer Replikation repetitive Sequenzen ihres im Virion zu verpackenden Genoms, die – vor oder beim Verpacken – durch virale Nukleasen in einzelne Wiederholungseinheiten gespalten werden.[2][3][4][5]

Einzelnachweise

  1. ↑ A. Basu, S. Mazor, J. R. Casey: Distance measurements within a concatamer of the plasma membrane Cl⁻/HCO₃⁻ exchanger, AE1. In: Biochemistry. Band 49, Nummer 43, November 2010, ISSN 1520-4995, S. 9226–9240, doi:10.1021/bi101134h, PMID 20828148.
  2. ↑ H. Fujisawa, M. Morita: Phage DNA packaging. In: Genes to cells : devoted to molecular & cellular mechanisms. Band 2, Nummer 9, September 1997, ISSN 1356-9597, S. 537–545, PMID 9413995.
  3. ↑ V. B. Rao, M. Feiss: The bacteriophage DNA packaging motor. In: Annual Review of Genetics. Band 42, 2008, ISSN 0066-4197, S. 647–681, doi:10.1146/annurev.genet.42.110807.091545, PMID 18687036.
  4. ↑ M. J. Culyba, J. E. Harrison, Y. Hwang, F. D. Bushman: DNA cleavage by the A22R resolvase of vaccinia virus. In: Virology. Band 352, Nummer 2, September 2006, ISSN 0042-6822, S. 466–476, doi:10.1016/j.virol.2006.05.007, PMID 16781759.
  5. ↑ G. Morissette, L. Flamand: Herpesviruses and chromosomal integration. In: Journal of virology. Band 84, Nummer 23, Dezember 2010, ISSN 1098-5514, S. 12100–12109, doi:10.1128/JVI.01169-10, PMID 20844040, PMC 2976420 (freier Volltext).

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