Entactin

Vorhandene Strukturdaten: PDB 1NDX

Entactin
Entactin
Entactin
Bändermodell von Entactin, nach PDB 1GL4
Andere Namen
  • Nidogen
  • Nidogen-1 (NID-1)

Vorhandene Strukturdaten: PDB 1NDX

Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 1.247 Aminosäuren, 136.377 Da
Bezeichner
Gen-Namen NID1, NID
Externe IDs
Vorkommen
Homologie-Familie Hovergen
Übergeordnetes Taxon Eumetazoa
Orthologe
Mensch Hausmaus
Entrez 4811 18073
Ensembl ENSG00000116962 ENSMUSG00000005397
UniProt P14543 P10493
Refseq (mRNA) NM_002508 NM_010917
Refseq (Protein) NP_002499 NP_035047
Genlocus Chr 1: 235.98 – 236.07 Mb Chr 13: 13.44 – 13.51 Mb
PubMed-Suche 4811 18073

Entactin oder Nidogen ist ein Glykoprotein, das in der Basalmembran von Zellen exprimiert wird und aus drei globulären Domänen (G1, G2 und G3) besteht. Die G3-Domäne kann an das Glykoprotein Laminin binden, die G2 Domäne an Zellen und Kollagen IV. So ist Entactin als Teil der extrazellulären Matrix netzwerkbildend und spielt bei Zellinteraktionen eine Rolle.[1]

Literatur

  • Albert E. Chung, Li-Jin Dong, Chuanyue Wu, Marian E. Durkin: Biological functions of entactin. In: Kidney International. Band 43, Nr. 1, 1993, S. 13–19, doi:10.1038/ki.1993.4.
  • D. Reinhardt, K. Mann, R. Nischt, J. W. Fox, M. L. Chu, T. Krieg, R. Timpl: Mapping of nidogen binding sites for collagen type IV, heparan sulfate proteoglycan, and zinc. In: Journal of Biological Chemistry. Band 268, Nr. 15, 1993, S. 10881–10887, doi:10.1016/S0021-9258(18)82067-1.
  • Li-Jin Dong, Jyh-Cheng Hsieh, Albert E. Chung: Two Distinct Cell Attachment Sites in Entactin Are Revealed by Amino Acid Substitutions and Deletion of the RGD Sequence in the Cysteine-rich Epidermal Growth Factor Repeat 2 (∗). In: Journal of Biological Chemistry. Band 270, Nr. 26, 1995, S. 15838–15843, doi:10.1074/jbc.270.26.15838.
  • P. D. Yurchenco, J. C. Schittny: Molecular architecture of basement membranes. In: FASEB J. 6. Auflage. Band 4, 1990, S. 1577–90, doi:10.1096/fasebj.4.6.2180767, PMID 2180767 (semanticscholar.org).

Einzelnachweise

  1. ↑ A. E. Chung, M. E. Durkin: Entactin: structure and function. In: American Journal of Respiratory Cell and Molecular Biology. Band 3, Nr. 4, 1990, S. 275–282, doi:10.1165/ajrcmb/3.4.275, PMID 2119632.

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