Integrin α-IIb
| Integrin alpha-IIb | ||
|---|---|---|
| Andere Namen |
GPalpha IIb, GPIIb, ITGA2B | |
| Eigenschaften des menschlichen Proteins | ||
| Masse/Länge Primärstruktur | 1.039 Aminosäuren, 113.377 Da | |
| Bezeichner | ||
| Externe IDs | ||
| Vorkommen | ||
| Homologie-Familie | Hovergen | |
Integrin α-IIb (synonym CD41) ist ein Oberflächenprotein aus der Gruppe der Integrine.
Eigenschaften
Integrin α-IIb ist ein Zelladhäsionsmolekül und bildet mit Integrin β-3 einen heterodimeren Rezeptor für Fibronectin, Fibrinogen, Plasminogen, Prothrombin, Thrombospondin und Vitronectin. Integrin α-IIb bindet an die Aminosäuresequenz RGD in verschiedenen Proteinen und an HHLGGGAKQAGDV in der γ-Kette von Fibrinogen. Es wird von Thrombozyten, Megakaryozyten und HSC (prä-HSC Typ II)[1] gebildet. Integrin α-IIb ist glykosyliert und besitzt eine Pyrrolidoncarboxylsäure.
Weblinks
Einzelnachweise
- ↑ A. Liakhovitskaia, S. Rybtsov, T. Smith, A. Batsivari, N. Rybtsova, C. Rode, M. de Bruijn, F. Buchholz, S. Gordon-Keylock, S. Zhao, A. Medvinsky: Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this. In: Development. Band 141, Nummer 17, September 2014, S. 3319–3323, doi:10.1242/dev.110841, PMID 25139854, PMC 4199125 (freier Volltext).
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