Limbatustoxin

Limbatotoxin, LbTx

Potassium channel toxin alpha-KTx 1.4
Andere Namen

Limbatotoxin, LbTx

Masse/Länge Primärstruktur 37 Aminosäuren, 4.042 Da
Bezeichner
Externe IDs

Limbatustoxin (synonym Kaliumkanaltoxin alpha-KTx 1.4, LbTx) ist ein Toxin aus dem Skorpion Centruroides limbatus.

Eigenschaften

Limbatustoxin ist ein Protein und Skorpiontoxin. Es bindet und hemmt Calcium-aktivierte Kaliumkanäle vom Typ maxi-K.[1] Limbatustoxin ist strukturell mit Charybdotoxin a, Charybdotoxin b, Iberiotoxin und ferner mit Noxiustoxin, Margatoxin und Tityustoxin Kα verwandt.[2]

Literatur

  • L. D. Possani, E. Merino, M. Corona, F. Bolivar, B. Becerril: Peptides and genes coding for scorpion toxins that affect ion-channels. In: Biochimie. Band 82, Nummer 9–10, 2000 Sep-Oct, S. 861–868, PMID 11086216.
  • S. P. Bush: Envenomation by the scorpion (Centruroides limbatus) outside its natural range and recognition of medically important scorpions. In: Wilderness & environmental medicine. Band 10, Nummer 3, 1999, S. 161–164, PMID 10560310.

Einzelnachweise

  1. ↑ O. B. McManus, L. M. Helms, L. Pallanck, B. Ganetzky, R. Swanson, R. J. Leonard: Functional role of the beta subunit of high conductance calcium-activated potassium channels. In: Neuron. Band 14, Nummer 3, März 1995, S. 645–650, PMID 7695911.
  2. ↑ Hervé Rochat: Animal Toxins. Springer Science & Business Media, 2000, ISBN 978-3-764-35983-6, S. 184.

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