Slotoxin

Slotoxin

Potassium channel toxin alpha-KTx 1.11
Andere Namen

Slotoxin

Masse/Länge Primärstruktur 37 Aminosäuren, 4.092 Da
Bezeichner
Externe IDs

Slotoxin (synonym Kaliumkanaltoxin alpha-KTx 1.11) ist ein Neurotoxin aus dem Skorpion Centruroides noxius.

Eigenschaften

Slotoxin ist ein Peptid und ein Skorpiontoxin aus dem Gift von Centruroides noxius, wie auch Noxiustoxin. Es bindet an calciumgesteuerte Kaliumkanäle und blockiert KCa1.1/KCNMA1 reversibel und KCNMA1 und KCNMB1 und in geringerem Umfang auch KCNMA1 und KCNMB4 irreversibel, nicht aber dSlo, Kv1.1/KCNA1, Kv11.1/KCNH2/ERG1, Kir2.2/KCNJ12, Shaker-IR, SK1/KCNN1, SK2/KCNN2 und SK3/KCNN3.[1] Slotoxin ist strukturell mit Charybdotoxin (αKTx1-Familie) verwandt.

Einzelnachweise

  1. ↑ J. Garcia-Valdes, F. Z. Zamudio, L. Toro, L. D. Possani, L. D. Possan: Slotoxin, alphaKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between alpha and alpha+beta (beta1 or beta4) complexes. In: FEBS letters. Band 505, Nummer 3, September 2001, S. 369–373, PMID 11576530.

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