Aleglitazar

Aleglitazar
Names
	Preferred IUPAC name (2S)-2-Methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid
	Other names Ro-0728804, R-1439
Identifiers
CAS Number	475479-34-6 ;
3D model (JSmol)	Interactive image; Interactive image;
ChEMBL	ChEMBL519504 ;
ChemSpider	8450255 ;
DrugBank	DB08915 ;
ECHA InfoCard	100.220.523
IUPHAR/BPS	7405;
KEGG	D08845 ;
PubChem CID	10274777;
UNII	41T4OAG59U ;
CompTox Dashboard (EPA)	DTXSID70197193 ;
	InChI InChI=1S/C24H23NO5S/c1-15-19(25-23(30-15)16-6-4-3-5-7-16)10-12-29-20-9-8-17(14-21(28-2)24(26)27)22-18(20)11-13-31-22/h3-9,11,13,21H,10,12,14H2,1-2H3,(H,26,27)/t21-/m0/s1 Key: DAYKLWSKQJBGCS-NRFANRHFSA-N ; InChI=1/C24H23NO5S/c1-15-19(25-23(30-15)16-6-4-3-5-7-16)10-12-29-20-9-8-17(14-21(28-2)24(26)27)22-18(20)11-13-31-22/h3-9,11,13,21H,10,12,14H2,1-2H3,(H,26,27)/t21-/m0/s1 Key: DAYKLWSKQJBGCS-NRFANRHFBF;
	SMILES CC1=C(CCOc2ccc(C[C@H](OC)C(O[H])=O)c3c2C=CS3)N=C(c4ccccc4)O1; O=C(O)[C@@H](OC)Cc4ccc(OCCc1nc(oc1C)c2ccccc2)c3c4scc3;
Properties
Chemical formula	C24H23NO5S
Molar mass	437.51 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Aleglitazar is a peroxisome proliferator-activated receptor agonist (hence a PPAR modulator) with affinity to PPARα and PPARγ, which was under development by Hoffmann–La Roche for the treatment of type II diabetes.^[1] It is no longer in phase III clinical trials.^[2]

References

^ "Statement on a nonproprietary name adopted by the USAN Council: Aleglitazar" (PDF). United States Adopted Names. American Medical Association. Retrieved 2008-08-17.
^ "Roche halts diabetes drug trial in blow to pipeline". Roche. 2013-07-10. Retrieved 2013-07-10.

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