CYP4A22

CYP4A22
Identifiers
Aliases	CYP4A22, cytochrome P450 family 4 subfamily A member 22
External IDs	OMIM: 615341; MGI: 3611747; HomoloGene: 134044; GeneCards: CYP4A22; OMA:CYP4A22 - orthologs
EC number	1.14.14.80
Gene location (Human)
Chr.	Chromosome 1 (human)
End	47,149,727 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	115,296,231 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; human kidney; ; testicle; ; subcutaneous adipose tissue; ; right lung; ; tibial nerve; ; gastric mucosa; ; Achilles tendon; ; olfactory zone of nasal mucosa; ; lactiferous gland;
	Top expressed in
	renal cortex; ; right kidney; ; proximal tubule; ; hepatobiliary system; ; liver; ; human kidney; ; outer renal medulla; ; respiratory epithelium; ; metanephros; ; nose;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; oxidoreductase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; monooxygenase activity; arachidonic acid omega-hydroxylase activity; laurate hydroxylase activity; 16-hydroxypalmitate dehydrogenase activity;
Cellular component	organelle membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; intracellular membrane-bounded organelle; extracellular space; integral component of membrane;
Biological process	lipid hydroxylation; omega-hydroxylase P450 pathway;
	Sources:Amigo / QuickGO
Orthologs
	284541
	13118
	ENSG00000162365
	ENSMUSG00000078597
	Q5TCH4
	A2A974
	NM_001010969; NM_001308102
	NM_172306; NM_007821
	NP_001010969; NP_001295031; NP_001295031.1
	NP_758510
	Wikidata
View/Edit Human	View/Edit Mouse

CYP4A22 (cytochrome P450, family 4, subfamily A, polypeptide 22) also known as fatty acid omega-hydroxylase is a protein which in humans is encoded by the CYP4A22 gene.^[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33.^[6]

CYP4A22 was once considered, along with CYP4A11, CYP4F2, and CYP4F3, as active in metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) by an omega oxidation reaction with the predominant 20-HETE-synthesizing enzymes in humans being CYP4F2 followed by CYP4A11; 20-HETE regulates blood flow, vascularization, blood pressure, and kidney tubule absorption of ions in rodents and possibly humans.^[7] However, human CYP4A22 is expressed at very low levels in few tissues and may not be a functional enzyme in regard to the metabolism of arachidonic acid to 20-HETE.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162365 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000078597 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hiratsuka M, Nozawa H, Katsumoto Y, Moteki T, Sasaki T, Konno Y, Mizugaki M (Jul 2006). "Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population". Mutation Research. 599 (1–2): 98–104. doi:10.1016/j.mrfmmm.2006.02.008. PMID 16806293.
^ This article incorporates public domain material from "Entrez Gene: CYP4A22". Reference Sequence collection. National Center for Biotechnology Information.
^ Hoopes SL, Garcia V, Edin ML, Schwartzman ML, Zeldin DC (Jul 2015). "Vascular actions of 20-HETE". Prostaglandins & Other Lipid Mediators. 120: 9–16. doi:10.1016/j.prostaglandins.2015.03.002. PMC 4575602. PMID 25813407.
^ Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH (Jan 2005). "Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension". Circulation. 111 (1): 63–9. CiteSeerX 10.1.1.335.1764. doi:10.1161/01.CIR.0000151309.82473.59. PMID 15611369.
^ Edson KZ, Rettie AE (2013). "CYP4 enzymes as potential drug targets: focus on enzyme multiplicity, inducers and inhibitors, and therapeutic modulation of 20-hydroxyeicosatetraenoic acid (20-HETE) synthase and fatty acid ω-hydroxylase activities". Current Topics in Medicinal Chemistry. 13 (12): 1429–40. doi:10.2174/15680266113139990110. PMC 4245146. PMID 23688133.

External links

Human CYP4A22 genome location and CYP4A22 gene details page in the UCSC Genome Browser.

Bellamine A, Wang Y, Waterman MR, Gainer JV, Dawson EP, Brown NJ, Capdevila JH (Jan 2003). "Characterization of the CYP4A11 gene, a second CYP4A gene in humans". Archives of Biochemistry and Biophysics. 409 (1): 221–7. doi:10.1016/S0003-9861(02)00545-3. PMID 12464262.
Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH (Jan 2005). "Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension". Circulation. 111 (1): 63–9. CiteSeerX 10.1.1.335.1764. doi:10.1161/01.CIR.0000151309.82473.59. PMID 15611369.
Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (Jan 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162365 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000078597 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16806293-5] Hiratsuka M, Nozawa H, Katsumoto Y, Moteki T, Sasaki T, Konno Y, Mizugaki M (Jul 2006). "Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population". Mutation Research. 599 (1–2): 98–104. doi:10.1016/j.mrfmmm.2006.02.008. PMID 16806293.

[entrez-6] This article incorporates public domain material from "Entrez Gene: CYP4A22". Reference Sequence collection. National Center for Biotechnology Information.

[7] Hoopes SL, Garcia V, Edin ML, Schwartzman ML, Zeldin DC (Jul 2015). "Vascular actions of 20-HETE". Prostaglandins & Other Lipid Mediators. 120: 9–16. doi:10.1016/j.prostaglandins.2015.03.002. PMC 4575602. PMID 25813407.

[8] Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH (Jan 2005). "Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension". Circulation. 111 (1): 63–9. CiteSeerX 10.1.1.335.1764. doi:10.1161/01.CIR.0000151309.82473.59. PMID 15611369.

[9] Edson KZ, Rettie AE (2013). "CYP4 enzymes as potential drug targets: focus on enzyme multiplicity, inducers and inhibitors, and therapeutic modulation of 20-hydroxyeicosatetraenoic acid (20-HETE) synthase and fatty acid ω-hydroxylase activities". Current Topics in Medicinal Chemistry. 13 (12): 1429–40. doi:10.2174/15680266113139990110. PMC 4245146. PMID 23688133.

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CYP4A22

References

External links

Further reading