CYP76 family

Cytochrome P450, family 76, also known as CYP76, is a cytochrome P450 family in land plants,^[1]^[2] related to the biosynthesis of many plant monoterpenes and diterpenes such as 8-hydroxygeraniol,^[3]^[2] tanshinone and alkannin.^[4]^[5] The first gene identified in this family is the CYP76A1 and CYP76A2 from the eggplant.^[1]

References

^ ^a ^b Toguri, T; Kobayashi, O; Umemoto, N (19 October 1993). "The cloning of eggplant seedling cDNAs encoding proteins from a novel cytochrome P-450 family (CYP76)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1216 (1): 165–9. doi:10.1016/0167-4781(93)90058-l. PMID 8218411.
^ ^a ^b Höfer, R; Dong, L; André, F; Ginglinger, JF; Lugan, R; Gavira, C; Grec, S; Lang, G; Memelink, J; Van der Krol, S; Bouwmeester, H; Werck-Reichhart, D (November 2013). "Geraniol hydroxylase and hydroxygeraniol oxidase activities of the CYP76 family of cytochrome P450 enzymes and potential for engineering the early steps of the (seco)iridoid pathway". Metabolic Engineering. 20: 221–32. doi:10.1016/j.ymben.2013.08.001. PMID 23933465.
^ Collu G, Unver N, Peltenburg-Looman AM, van der Heijden R, Verpoorte R, Memelink J (November 2001). "Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis". FEBS Letters. 508 (2): 215–20. doi:10.1016/s0014-5793(01)03045-9. PMID 11718718. S2CID 45615763.
^ Höfer, R; Boachon, B; Renault, H; Gavira, C; Miesch, L; Iglesias, J; Ginglinger, JF; Allouche, L; Miesch, M; Grec, S; Larbat, R; Werck-Reichhart, D (November 2014). "Dual function of the cytochrome P450 CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides". Plant Physiology. 166 (3): 1149–61. doi:10.1104/pp.114.244814. PMC 4226383. PMID 25082892.
^ Bathe, Ulschan; Frolov, Andrej; Porzel, Andrea; Tissier, Alain (11 December 2019). "CYP76 Oxidation Network of Abietane Diterpenes in Lamiaceae Reconstituted in Yeast". Journal of Agricultural and Food Chemistry. 67 (49): 13437–13450. doi:10.1021/ACS.JAFC.9B00714. PMID 30994346.

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[eggplant-1] Toguri, T; Kobayashi, O; Umemoto, N (19 October 1993). "The cloning of eggplant seedling cDNAs encoding proteins from a novel cytochrome P-450 family (CYP76)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1216 (1): 165–9. doi:10.1016/0167-4781(93)90058-l. PMID 8218411.

[pmid23933465-2] Höfer, R; Dong, L; André, F; Ginglinger, JF; Lugan, R; Gavira, C; Grec, S; Lang, G; Memelink, J; Van der Krol, S; Bouwmeester, H; Werck-Reichhart, D (November 2013). "Geraniol hydroxylase and hydroxygeraniol oxidase activities of the CYP76 family of cytochrome P450 enzymes and potential for engineering the early steps of the (seco)iridoid pathway". Metabolic Engineering. 20: 221–32. doi:10.1016/j.ymben.2013.08.001. PMID 23933465.

[3] Collu G, Unver N, Peltenburg-Looman AM, van der Heijden R, Verpoorte R, Memelink J (November 2001). "Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis". FEBS Letters. 508 (2): 215–20. doi:10.1016/s0014-5793(01)03045-9. PMID 11718718. S2CID 45615763.

[4] Höfer, R; Boachon, B; Renault, H; Gavira, C; Miesch, L; Iglesias, J; Ginglinger, JF; Allouche, L; Miesch, M; Grec, S; Larbat, R; Werck-Reichhart, D (November 2014). "Dual function of the cytochrome P450 CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides". Plant Physiology. 166 (3): 1149–61. doi:10.1104/pp.114.244814. PMC 4226383. PMID 25082892.

[5] Bathe, Ulschan; Frolov, Andrej; Porzel, Andrea; Tissier, Alain (11 December 2019). "CYP76 Oxidation Network of Abietane Diterpenes in Lamiaceae Reconstituted in Yeast". Journal of Agricultural and Food Chemistry. 67 (49): 13437–13450. doi:10.1021/ACS.JAFC.9B00714. PMID 30994346.

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