COUP-TFII

El factor de transcripción COUP2 (COUP-TFII), también conocido como NR2F2 (de sus siglas en inglés "Nuclear receptor subfamily 2, group F, member 2"), es una…

COUP-TFII
Factor de transcripción COUP2
Estructuras disponibles
PDB Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos COUP-TFII (HGNC: 7976) ARP1; COUP-TFII; COUPTFB; MGC117452; SVP40; TFCOUP2
Identificadores
externos
  • GeneCards: Gen COUP-TFII
  • UniProt: COUP-TFII
    • Locus Cr. 15 q26.2
    Ortólogos
    Especies
    Humano Ratón
    Entrez
    7026
    UniProt
    P24468 n/a
    RefSeq
    (ARNm)
    NP_066285 n/a
    [editar datos en Wikidata]

    El factor de transcripción COUP2 (COUP-TFII), también conocido como NR2F2 (de sus siglas en inglés "Nuclear receptor subfamily 2, group F, member 2"), es una proteína codificada en humanos por el gen HGNC NR2F2 .[1]​

    COUP-TFII juega un papel crucial en el control del desarrollo de un cierto número de tejidos y órganos incluido el corazón, los vasos sanguíneos, el músculo y los miembros.[2]​[3]​ El receptor de glucocorticoides (GR) estimula la transactivación inducida por COUP-TFII, mientras que COUP-TFII reprime la actividad transcripcional de GR.[4]​[5]​ COUP-TFII interacciona con GATA2 para inhibir la diferenciación de los adipocitos.[6]​

    Interacciones

    La proteína COUP-TFII ha demostrado ser capaz de interaccionar con:

    Referencias

    1. ↑ «Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2». 
    2. ↑ Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (abril de 1999). «The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development». Genes Dev. 13 (8): 1037-49. PMC 316637. PMID 10215630. doi:10.1128/MCB.24.24.10835-10843.2004. 
    3. ↑ Lee CT, Li L, Takamoto N, Martin JF, Demayo FJ, Tsai MJ, Tsai SY (diciembre de 2004). «The nuclear orphan receptor COUP-TFII is required for limb and skeletal muscle development». Mol. Cell. Biol. 24 (24): 10835-43. PMC 533959. PMID 15572686. doi:10.1128/MCB.24.24.10835-10843.2004. 
    4. ↑ De Martino MU, Bhattachryya N, Alesci S, Ichijo T, Chrousos GP, Kino T (abril de 2004). «The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism». Mol. Endocrinol. 18 (4): 820-33. PMID 14739255. doi:10.1210/me.2003-0341. 
    5. ↑ De Martino MU, Alesci S, Chrousos GP, Kino T (junio de 2004). «Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism». Ann. N. Y. Acad. Sci. 1024: 72-85. PMID 15265774. doi:10.1196/annals.1321.006. 
    6. ↑ Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED (febrero de 2008). «The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis». Proc. Natl. Acad. Sci. U.S.A. 105 (7): 2421-6. PMID 18250317. doi:10.1073/pnas.0707082105. 
    7. ↑ Smirnov, D A; Hou S, Ricciardi R P (Mar. de 2000). «Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription». Virology (UNITED STATES) 268 (2): 319-28. ISSN 0042-6822. PMID 10704340. doi:10.1006/viro.1999.0181. 
    8. ↑ Avram, D; Ishmael J E, Nevrivy D J, Peterson V J, Lee S H, Dowell P, Leid M (mayo. de 1999). «Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2». J. Biol. Chem. (UNITED STATES) 274 (20): 14331-6. ISSN 0021-9258. PMID 10318855. 
    9. ↑ Marcus, S L; Winrow C J, Capone J P, Rachubinski R A (Nov. de 1996). «A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor». J. Biol. Chem. (UNITED STATES) 271 (44): 27197-200. ISSN 0021-9258. PMID 8910285. 

    Content Disclaimer

    Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

    1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
    2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
    3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
    4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
    5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.