Ibogamina

La ibogamina es un alcaloide que se encuentra en Tabernanthe iboga.[2]​[3]​

Ibogamina
 
Ibogamina
Nombre IUPAC
[6R-(6.alpha.,6a.beta.,7.beta.,9.alpha.)]-7-ethyl-6,6a,7,8,9,10,12,13-octahydro-6,9-methano-5H-pyrido[1',2':1,2]azepino[4,5-b]indole
General
Fórmula estructural Imagen de la estructura
Fórmula molecular C
19H
24N
2
Identificadores
Número CAS 481-87-8[1]​
ChEBI 5853
ChemSpider 90568
PubChem 100217
KEGG C09215
InChI=1S/C19H24N2/c1-2-13-9-12-10-16-18-15(7-8-21(11-12)19(13)16)14-5-3-4-6-17(14)20-18/h3-6,12-13,16,19-20H,2,7-11H2,1H3/t12-,13+,16+,19+/m1/s1
Key: LRLCVRYKAFDXKU-YGOSVGOTSA-N
Propiedades físicas
Masa molar 280,41 g/mol
Valores en el SI y en condiciones estándar
(25 ℃ y 1 atm), salvo que se indique lo contrario.
[editar datos en Wikidata]

La ibogamina es un alcaloide que se encuentra en Tabernanthe iboga.[2]​[3]​

La investigación básica relacionada con cómo la adicción afecta el cerebro ha utilizado esta sustancia química.[4]​

La ibogamina redujo la autoadministración de cocaína y la morfina en ratas, siendo más consistente que otros alcaloides iboga, incluso la ibogaína.[5]​

Referencias

  1. ↑ Número CAS
  2. ↑ Bartlett, M. F.; Dickel, D. F.; Taylor, W. I. (1958). «The Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine - Journal of the American Chemical Society (ACS Publications)». Journal of the American Chemical Society 80 (1): 126. doi:10.1021/ja01534a036. 
  3. ↑ Kuehne, Martin E.; Reider, Paul J. (1985). «A synthesis of ibogamine - The Journal of Organic Chemistry (ACS Publications)». The Journal of Organic Chemistry 50 (9): 1464. doi:10.1021/jo00209a020. 
  4. ↑ Levi MS, Borne RF (octubre de 2002). «A review of chemical agents in the pharmacotherapy of addiction». Curr. Med. Chem. 9 (20): 1807-18. PMID 12369879. 
  5. ↑ Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN (septiembre de 1994). «Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum.». Brain Res. 657 (1-2): 14-22. PMID 7820611. doi:10.1016/0006-8993(94)90948-2. 

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