PRPF6

PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
Identificadores
Símbolos PRPF6 (HGNC: 15860) ANT-1; C20orf14; TOM; U5-102K; hPrp6
Identificadores
externos
  • GeneCards: Gen PRPF6
  • UniProt: PRPF6
    • Ortólogos
    Especies
    Humano Ratón
    Entrez
    24148
    RefSeq
    (ARNm)
    NP_036601 n/a
    [editar datos en Wikidata]

    El factor 6 de procesamiento del pre-ARNm (PRPF6) es una proteína codificada en humanos por el gen PRPF6.[1]​[2]​[3]​

    La proteína codificada por este gen parece estar implicada en el proceso de splicing alternativo del pre-ARNm, posiblemente actuando como un factor puente entre los snRNPs U5 y U4/U6 en formación del espliceosoma. Esta proteína también puede unirse al receptor androgénico, proveyendo de un nexo de unión entre la activación transcripcional y el splicing.[3]​

    Interacciones

    La proteína PRPF6 ha demostrado ser capaz de interaccionar con:

    Referencias

    1. ↑ Nishikimi A, Mukai J, Kioka N, Yamada M (Jan de 2000). «A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors». Biochim Biophys Acta 1435 (1-2): 147-52. PMID 10561546. 
    2. ↑ Makarov EM, Makarova OV, Achsel T, Luhrmann R (Jun de 2000). «The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions». J Mol Biol 298 (4): 567-75. PMID 10788320. doi:10.1006/jmbi.2000.3685. 
    3. ↑ a b «Entrez Gene: PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)». 
    4. ↑ Sun, Xiaojing; Zhang Hua, Wang Dan, Ma Dalong, Shen Yan, Shang Yongfeng (Jul. de 2004). «DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression». J. Biol. Chem. (United States) 279 (31): 32839-47. ISSN 0021-9258. PMID 15161931. doi:10.1074/jbc.M402522200. 
    5. ↑ Yuryev, Anton; Wennogle Lawrence P (Feb. de 2003). «Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis». Genomics (United States) 81 (2): 112-25. ISSN 0888-7543. PMID 12620389. 
    6. ↑ Yuryev, A; Ono M, Goff S A, Macaluso F, Wennogle L P (Jul. de 2000). «Isoform-specific localization of A-RAF in mitochondria». Mol. Cell. Biol. (UNITED STATES) 20 (13): 4870-8. ISSN 0270-7306. PMID 10848612. 
    7. ↑ Zhao, Yue; Goto Kiminobu, Saitoh Masayuki, Yanase Toshihiko, Nomura Masatoshi, Okabe Taijiro, Takayanagi Ryoichi, Nawata Hajime (Aug. de 2002). «Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor». J. Biol. Chem. (United States) 277 (33): 30031-9. ISSN 0021-9258. PMID 12039962. doi:10.1074/jbc.M203811200. 

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