RCOR1

Correpresor 1 REST

Estructura tridimensional de la proteína RCOR1.
Estructuras disponibles
PDB Buscar ortólogos: PDBe, RCSB
Lista de códigos PDB
2iw5
Identificadores
Símbolos RCOR1 (HGNC: 17441) COREST; KIAA0071; RCOR
Identificadores
externos
  • GeneCards: Gen RCOR1
  • UniProt: RCOR1
    • Locus Cr. 14 q32.31-q32.32
    Ortólogos
    Especies
    Humano Ratón
    Entrez
    23186
    UniProt
    Q9UKL0 n/a
    RefSeq
    (ARNm)
    NP_055971 n/a
    Información relacionada
    Articulos relacionados Publicaciones sobre RCOR1 en Google académico,Publicaciones sobre RCOR1 en PubMed
    [editar datos en Wikidata]

    El correpresor 1 REST (RCOR1) es una proteína codificada en humanos por el gen RCOR1.[1]​[2]​

    El gen RCOR1 codifica un correpresor funcional necesario para la regulación específica de la expresión génica a nivel neural.[2]​

    Interacciones

    La proteína RCOR1 ha demostrado ser capaz de interaccionar con:

    Significación clínica

    Existen 92 enfermedades descritas que coinciden con RCOR1[6]​

    Referencias

    1. ↑ a b Andrés, M E; Burger C, Peral-Rubio M J, Battaglioli E, Anderson M E, Grimes J, Dallman J, Ballas N, Mandel G (Aug. de 1999). «CoREST: a functional corepressor required for regulation of neural-specific gene expression». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (17): 9873-8. ISSN 0027-8424. PMID 10449787. 
    2. ↑ a b «Entrez Gene: RCOR1 REST corepressor 1». 
    3. ↑ a b c d Hakimi, Mohamed-Ali; Bochar Daniel A, Chenoweth Josh, Lane William S, Mandel Gail, Shiekhattar Ramin (mayo. de 2002). «A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes». Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (11): 7420-5. ISSN 0027-8424. PMID 12032298. doi:10.1073/pnas.112008599. 
    4. ↑ a b You, A; Tong J K, Grozinger C M, Schreiber S L (Feb. de 2001). «CoREST is an integral component of the CoREST- human histone deacetylase complex». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (4): 1454-8. ISSN 0027-8424. PMID 11171972. doi:10.1073/pnas.98.4.1454. 
    5. ↑ Iwase, Shigeki; Januma Aya, Miyamoto Kiyoko, Shono Naomi, Honda Arata, Yanagisawa Junn, Baba Tadashi (Sep. de 2004). «Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression». Biochem. Biophys. Res. Commun. (United States) 322 (2): 601-8. ISSN 0006-291X. PMID 15325272. doi:10.1016/j.bbrc.2004.07.163. 
    6. ↑ «MalaCards». Consultado el 24 de diciembre de 2025. 

    Enlaces externos

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