TLN1

Pour l’article ayant un titre homophone, voir Tallinn.

TLN1
TLN1
Structure de la protéine TLN1. Basé sur l'identification PDB 1mix.
Structures disponibles
PDBRecherche d'orthologue : PDBe RCSB
Identifiants
AliasTLN1
IDs externesOMIM: 186745 MGI: 1099832 HomoloGene: 21267 GeneCards: TLN1
Wikidata
Voir/Editer HumainVoir/Editer Souris

La TLN1 ou taline 1 est une protéine cytosolique. Elle est codée par le gène TLN1 situé sur le chromosome 9 humain.

Structure

La famille des talines comprend deux protéines, appelées taline 1 et taline 2[5].

Rôles

Elle sert à relier l'actine aux intégrines. Elle intervient dans l'adhésion des plaquettes sanguines[6] aussi bien que dans la stabilisation des podocytes dans le glomérule rénal[7].

Notes et références

  1. a b et c GRCh38: Ensembl release 89: ENSG00000137076 - Ensembl, May 2017
  2. a b et c GRCm38: Ensembl release 89: ENSMUSG00000028465 - Ensembl, May 2017
  3. « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
  4. « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
  5. Debrand E, El Jai Y, Spence L et al. Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms, FEBS J, 2009;276:1610–162
  6. Nieswandt B, Moser M, Pleines I et al. Loss of talin1 in platelets abrogates ntegrin activation, platelet aggregation, and thrombus formation in vitro and in vivo, J Exp Med, 2007;204:3113–3118
  7. Tian X, Kim JJ, Monkley SM, Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance, J Clin Invest, 2014

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