ビタミンC誘導体(ビタミンシーゆうどうたい、Vitamin C Derivatives)とは、ビタミンC(L-アスコルビン酸)を改良した誘導体。またプロビタミンCは、生体内で酵素反応によりビタミンC(L-アスコルビン酸)となるもの[1]。ビタミンCは強い抗酸化作用があるが不安定で分子構造が壊れやすい。そのため、ビタミンC誘導体では物質として安定化したり(分解しにくい)、皮膚への吸収性や皮膚乾燥の副作用を改良している。1940年代には食品添加物として利用され1960年代には美容目的に使用されるようになり色素沈着抑制[2]、ニキビなどに使用される。日本で医薬部外品として認可された美白有効成分には複数のビタミンC誘導体が含まれる[3]。イオン導入や[4]、ケミカルピーリング後に塗布される[5]。
^ abMurtaza F, Bangash AR, Khushdil A; et al (2016-7). “Efficacy of Trichloro-Acetic Acid Peel Alone Versus Combined Topical Magnesium Ascorbyl Phosphate for Epidermal Melasma”. Journal of the College of Physicians and Surgeons26 (7): 557–561. PMID27504543.
^S. R. Pinnell, H. Yang, M. Omar; et al (2001-2). “Topical L-ascorbic acid: percutaneous absorption studies”. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]27 (2): 137–142. PMID11207686.
^Victoria-Martínez, Ana M.; Mercader-García, Pedro (2017). “Allergic Contact Dermatitis to 3-o-Ethyl-L-Ascorbic Acid in Skin-lightening Cosmetics”. Dermatitis28 (1): 89. doi:10.1097/DER.0000000000000260. PMID28002235.
^Mamodaly, Myriam; Dereure, Olivier; Raison‐Peyron, Nadia (2019). “A new case of allergic contact dermatitis caused by 3-o-ethyl ascorbic acid in facial antiageing cosmetics”. Contact Dermatitis. doi:10.1111/cod.13307. PMID31066077.
^Woolery-Lloyd, Heather; Baumann, Leslie; Ikeno, Hiroshi (2010). “Sodium L-ascorbyl-2-phosphate 5% lotion for the treatment of acne vulgaris: a randomized, double-blind, controlled trial”. Journal of Cosmetic Dermatology9 (1): 22–27. doi:10.1111/j.1473-2165.2010.00480.x. PMID20367669.
^Klock J, Ikeno H, Ohmori K; et al (June 2005). “Sodium ascorbyl phosphate shows in vitro and in vivo efficacy in the prevention and treatment of acne vulgaris”. Int J Cosmet Sci (3): 171–6. doi:10.1111/j.1467-2494.2005.00263.x. PMID18492184.
^Khan, H.; Akhtar, N.; Ali, A. (2016). “Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers”. Drug Research67 (1): 52–58. doi:10.1055/s-0042-118171. PMID27756097.
^ abRuamrak, C.; Lourith, N.; Natakankitkul, S. (2009). “Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment”. International Journal of Cosmetic Science31 (1): 41–46. doi:10.1111/j.1468-2494.2008.00479.x. PMID19134126.
^Ishikawa, Yuko; Niwano, Takao; Hirano, Shinichi; et al (2019). “Whitening effect of l-ascorbate-2-phosphate trisodium salt on solar lentigos”. Archives of Dermatological Research311 (3): 183–191. doi:10.1007/s00403-019-01892-2. PMID30778667.
^Shimabukuro, Yoshio; Nakayama, Yohei; Ogata, Yorimasa; et al (2015). “Effects of an Ascorbic Acid–Derivative Dentifrice in Patients With Gingivitis: A Double-Masked, Randomized, Controlled Clinical Trial”. Journal of Periodontology86 (1): 27–35. doi:10.1902/jop.2014.140138. PMID25277459.
^INUI, Shigeki; ITAMI, Satoshi (2007). “Perifollicular pigmentation is the first target for topical vitamin C derivative ascorbyl 2-phosphate 6-palmitate (APPS): Randomized, single-blinded, placebo-controlled study”. The Journal of Dermatology34 (3): 221–223. doi:10.1111/j.1346-8138.2007.00256.x. PMID17291309.
^Richard E. Fitzpatrick, Elizabeth F. Rostan (2002-3). “Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage”. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]28 (3): 231–236. PMID11896774.
Stamford, Nicholas P J (2012). “Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives”. Journal of Cosmetic Dermatology11 (4): 310–317. doi:10.1111/jocd.12006. PMID23174055.