BCL10
2MB9
BCL10（B-cell lymphoma/leukemia 10）は、ヒトではBCL10遺伝子にコードされるタンパク質である[5][6]。BCL2、BCL3、BCL5、BCL6、BCL7A、BCL9と同様、リンパ腫において臨床的に重要である。
機能
BCL10は、MALTリンパ腫の症例で観察された染色体転座から同定された。この遺伝子にコードされるタンパク質はCARDドメインを持ち、アポトーシスの誘導とNF-κBの活性化を行うことが示されている。このタンパク質はCARD9、CARD10、CARD11、CARD14など、他のCARD-CCファミリーのタンパク質と相互作用することが報告されている。これらはNF-κBシグナル伝達に上流の調節因子として機能すると考えられている。このタンパク質はパラカスパーゼMALT1と複合体を形成する。MALT1はMALTリンパ腫において転座が知られている他の遺伝子にコードされるタンパク質である。MALT1とBCL10は相乗的にNF-κBを活性化すると考えられており、どちらの調節異常も同じ病理的過程に寄与して悪性腫瘍の形成をもたらす[6]。BCL10は刺胞動物以降で進化的に保存されており、ゼブラフィッシュからヒトまで機能的に保存されていることが示されている[7][8]。上流のCARD-CCファミリーと同様にBCL10は昆虫や線虫には存在せず、BCL10とCARD-CCタンパク質の系統分布の相関からは保存された複合体であることが示される。
相互作用
BCL10は次に挙げる因子と相互作用することが示されている。
出典
- ^ a b c GRCh38: Ensembl release 89: ENSG00000142867 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028191 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types”. Cell 96 (1): 35–45. (March 1999). doi:10.1016/S0092-8674(00)80957-5. PMID 9989495.
- ^ a b “Entrez Gene: BCL10 B-cell CLL/lymphoma 10”. 2021年12月12日閲覧。
- ^ “Functional characterization of zebrafish. (Danio rerio) Bcl10”. PLOS ONE 10 (4): e0122365. (April 2015). Bibcode:2015PLoSO..1022365M. doi:10.1371/journal.pone.0122365. PMC 4388727. PMID 25849213.
- ^ “Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions”. Frontiers in Immunology 9: 1136. (2018). doi:10.3389/fimmu.2018.01136. PMC 5978004. PMID 29881386.
- ^ “CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B”. J. Biol. Chem. 275 (52): 41082–6. (Dec 2000). doi:10.1074/jbc.C000726200. PMID 11053425.
- ^ “Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B”. J. Biol. Chem. 276 (24): 21405–9. (June 2001). doi:10.1074/jbc.M102488200. PMID 11259443.
- ^ a b “CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B”. J. Biol. Chem. 276 (15): 11877–82. (April 2001). doi:10.1074/jbc.M010512200. PMID 11278692.
- ^ “Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes”. J. Immunol. 188 (6): 2493–7. (2012). doi:10.4049/jimmunol.1101502. PMC 3294148. PMID 22323537.
- ^ “NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation”. Proc. Natl. Acad. Sci. U.S.A. 105 (8): 3023–8. (February 2008). Bibcode:2008PNAS..105.3023W. doi:10.1073/pnas.0712313105. PMC 2268578. PMID 18287044.
- ^ “Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma”. Mol. Cell 6 (4): 961–7. (October 2000). doi:10.1016/S1097-2765(05)00086-9. PMID 11090634.
- ^ “Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein”. J. Biol. Chem. 275 (15): 11114–20. (April 2000). doi:10.1074/jbc.275.15.11114. PMID 10753917.
関連文献
- “Genetic alterations underlying the pathogenesis of MALT lymphoma”. Hematol. J. 3 (1): 10–3. (2003). doi:10.1038/sj.thj.6200146. PMID 11960389.
- “Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma”. Cancer Res. 56 (19): 4297–301. (1996). PMID 8813110.
- “CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10”. J. Biol. Chem. 274 (15): 9955–9961. (1999). doi:10.1074/jbc.274.15.9955. PMID 10187770.
- “Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase”. J. Biol. Chem. 274 (15): 9962–9968. (1999). doi:10.1074/jbc.274.15.9962. PMID 10187771.
- “mE10, a novel caspase recruitment domain-containing proapoptotic molecule”. J. Biol. Chem. 274 (15): 10287–10292. (1999). doi:10.1074/jbc.274.15.10287. PMID 10187815.
- “Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)”. Nat. Genet. 22 (1): 63–68. (1999). doi:10.1038/8767. PMID 10319863.
- “CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis”. J. Biol. Chem. 274 (25): 17946–17954. (1999). doi:10.1074/jbc.274.25.17946. PMID 10364242.
- “Absence of BCL10 mutations in human malignant mesothelioma”. Cell 97 (6): 684–686. (1999). doi:10.1016/S0092-8674(02)09765-9. PMID 10380921.
- “c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB”. J. Biol. Chem. 274 (29): 20127–20132. (1999). doi:10.1074/jbc.274.29.20127. PMID 10400625.
- “Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein”. J. Biol. Chem. 275 (15): 11114–11120. (2000). doi:10.1074/jbc.275.15.11114. PMID 10753917.
- “BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma”. Am. J. Pathol. 157 (4): 1147–1154. (2000). doi:10.1016/S0002-9440(10)64630-5. PMC 1850175. PMID 11021819.
- “CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B”. J. Biol. Chem. 275 (52): 41082–41086. (2001). doi:10.1074/jbc.C000726200. PMID 11053425.
- “Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma”. Mol. Cell 6 (4): 961–967. (2000). doi:10.1016/S1097-2765(05)00086-9. PMID 11090634.
- “vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma”. J. Biol. Chem. 276 (5): 3183–3187. (2001). doi:10.1074/jbc.C000792200. PMID 11113112.
- “Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure”. Cell 104 (1): 33–42. (2001). doi:10.1016/S0092-8674(01)00189-1. PMID 11163238.
- “Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B”. J. Biol. Chem. 276 (24): 21405–21409. (2001). doi:10.1074/jbc.M102488200. PMID 11259443.
- “Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway”. J. Biol. Chem. 276 (22): 19012–19019. (2001). doi:10.1074/jbc.M009984200. PMID 11262391.
- “CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B”. J. Biol. Chem. 276 (15): 11877–11882. (2001). doi:10.1074/jbc.M010512200. PMID 11278692.
- “Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation”. FEBS Lett. 496 (2–3): 121–127. (2001). doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.
外部リンク
- Human BCL10 genome location and BCL10 gene details page in the UCSC Genome Browser.
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