TRPM4
TRPM4（Transient receptor potential cation channel subfamily M member 4、TRPチャネルサブタイプM4）はメラスタチン-4（melastatin-4）とも呼…
TRPM4（Transient receptor potential cation channel subfamily M member 4、TRPチャネルサブタイプM4）はメラスタチン-4（melastatin-4）とも呼ばれる蛋白質であり、遺伝子TRPM4 でコードされる[1][2]。心筋細胞の表面に発現しており、心筋の電気活動に関与している。
このチャネルを薬物で阻害すると心筋梗塞の進行を抑制することが知られている[3]。
TRPM4はNMDA型グルタミン酸受容体（NMDAR）を構成するGluN2A, GluN2Bと結合する[4]。この相互作用はNMDARおよびTRPM4のチャネル機能には影響しないが、この相互作用がNMDA受容体を介した細胞死（興奮毒性）を引き起こす。相互作用はTRPM4のTwinFドメインおよびGluN2のI4ドメイン間で起きており、TRPM4側に結合し相互作用を阻害する薬剤が開発されている。
関連項目
出典
- ^ Xu XZ, Moebius F, Gill DL, Montell C (September 2001). “Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform”. Proc. Natl. Acad. Sci. U.S.A. 98 (19): 10692–7. doi:10.1073/pnas.191360198. PMC 58528. PMID 11535825.
- ^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). “International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels”. Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
- ^ “心筋梗塞抑制の新手法を発見”. 岡山大学 (2013年7月25日). 2015年5月3日閲覧。
- ^ Yan, Jing; Bengtson, C. Peter; Buchthal, Bettina; Hagenston, Anna M.; Bading, Hilmar (2020-10-09). “Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants” (英語). Science 370 (6513): eaay3302. doi:10.1126/science.aay3302. ISSN 0036-8075.
関連文献
- Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. 704. Berlin: Springer. pp. 700. ISBN 978-94-007-0264-6
- Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP (2002). “TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization”. Cell 109 (3): 397–407. doi:10.1016/S0092-8674(02)00719-5. PMID 12015988.
- Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP (2004). “TRPM4 regulates calcium oscillations after T cell activation”. Science 306 (5700): 1374–1377. doi:10.1126/science.1098845. PMID 15550671.
- Vennekens R, Nilius B (2007). “Insights into TRPM4 function, regulation and physiological role”. Handb Exp Pharmacol. Handbook of Experimental Pharmacology 179 (179): 269–85. doi:10.1007/978-3-540-34891-7_16. ISBN 978-3-540-34889-4. PMID 17217063.
- Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M (2007). “Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4”. Nat Immunol 8 (3): 312–320. doi:10.1038/ni1441. PMID 17293867.
- Barbet G, Demion M, Moura IC, Serafini N, Léger T, Vrtovsnik F, Monteiro RC, Guinamard R, Kinet JP, Launay P (2008). “The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells”. Nat Immunol 9 (10): 1148–56. doi:10.1038/ni.1648. PMC 2956271. PMID 18758465.
外部リンク
- TRPM4 protein, human - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス
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