2-Oksokiselina razranatog lanca dekarboksilaza

2-Oksokiselina razranatog lanca dekarboksilaza
Identifikatori
EC broj	4.1.1.72
CAS broj	63653-19-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

2-Oksokiselina razranatog lanca dekarboksilaza (EC 4.1.1.72, dekarboksilaya oksokiselina razgranatog lanca, dekarboksilaza alfa-keto kiselina razgranatog lanca, dekarboksilaza keto kiselina razgranatog lanca, BCKA, (3S)-3-metil-2-oksopentanoatna karboksilijaza) je enzim sa sistematskim imenom (3S)-3-metil-2-oksopentanoat karboksilijaza (formira 2-metilbutanal).^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

(3S)-3-metil-2-oksopentanoat

\rightleftharpoons

2-metilbutanal + CO₂

Ovaj enzim deluje na brojne 2-oksokiseline.

Reference

↑ Oku, H. and Kaneda, T. (1988). „Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase”. J. Biol. Chem. 263: 18386-18396. PMID 3142877.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

MeSH Branched-chain-2-oxoacid+decarboxylase

[1] Oku, H. and Kaneda, T. (1988). „Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase”. J. Biol. Chem. 263: 18386-18396. PMID 3142877.

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