4,5:9,10-diseko-3-hidroksi-5,9,17-trioksoandrosta-1(10),2-dien-4-oatna hidrolaza

4,5:9,10-diseko-3-hidroksi-5,9,17-trioksoandrosta-1(10),2-dien-4-oatna hidrolaza
Identifikatori
EC broj	3.7.1.17
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

4,5:9,10-diseko-3-hidroksi-5,9,17-trioksoandrosta-1(10),2-dien-4-oatna hidrolaza (EC 3.7.1.17, tesD (gen), hsaD (gen)) je enzim sa sistematskim imenom 4,5:9,10-diseko-3-hidroksi-5,9,17-trioksoandrosta-1(10),2-dien-4-oat hidrolaza (formira (2Z,4Z)-2-hidroksiheksa-2,4-dienoat).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1E,2Z)-3-hidroksi-5,9,17-triokso-4,5:9,10-disekoandrosta-1(10),2-dien-4-oat + H₂O

\rightleftharpoons

3-[(3aS,4S,7aS)-7a-metil-1,5-diokso-oktahidro-1H-inden-4-il]propanoat + (2Z,4Z)-2-hidroksiheksa-2,4-dienoat

Ovaj enzim učestvuje u bakterijskoj degradaciji steroidnog prstena.

Reference

↑ Horinouchi, M., Hayashi, T., Koshino, H., Kurita, T. and Kudo, T. (2005). „Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441”. Appl. Environ. Microbiol. 71: 5275-5281. PMID 16151114.
↑ Van der Geize, R., Yam, K., Heuser, T., Wilbrink, M.H., Hara, H., Anderton, M.C., Sim, E., Dijkhuizen, L., Davies, J.E., Mohn, W.W. and Eltis, L.D. (2007). „A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages”. Proc. Natl. Acad. Sci. USA 104: 1947-1952. PMID 17264217.
↑ Lack, N., Lowe, E.D., Liu, J., Eltis, L.D., Noble, M.E., Sim, E. and Westwood, I.M. (2008). „Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64: 2-7. PMID 18097091.
↑ Lack, N.A., Yam, K.C., Lowe, E.D., Horsman, G.P., Owen, R.L., Sim, E. and Eltis, L.D. (2010). „Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism”. J. Biol. Chem. 285: 434-443. PMID 19875455.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

MeSH 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate+hydrolase

[1] Horinouchi, M., Hayashi, T., Koshino, H., Kurita, T. and Kudo, T. (2005). „Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441”. Appl. Environ. Microbiol. 71: 5275-5281. PMID 16151114.

[2] Van der Geize, R., Yam, K., Heuser, T., Wilbrink, M.H., Hara, H., Anderton, M.C., Sim, E., Dijkhuizen, L., Davies, J.E., Mohn, W.W. and Eltis, L.D. (2007). „A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages”. Proc. Natl. Acad. Sci. USA 104: 1947-1952. PMID 17264217.

[3] Lack, N., Lowe, E.D., Liu, J., Eltis, L.D., Noble, M.E., Sim, E. and Westwood, I.M. (2008). „Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64: 2-7. PMID 18097091.

[4] Lack, N.A., Yam, K.C., Lowe, E.D., Horsman, G.P., Owen, R.L., Sim, E. and Eltis, L.D. (2010). „Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism”. J. Biol. Chem. 285: 434-443. PMID 19875455.

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