4-Kidroksi-tetrahidrodipikolinatna sintaza

4-Kidroksi-tetrahidrodipikolinatna sintaza
Identifikatori
EC broj	4.3.3.7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

4-Kidroksi-tetrahidrodipikolinatna sintaza (EC 4.3.3.7, dihidropikolinatna sintetaza, dihidrodipikolinsko kiselinska sintaza, L-aspartat-4-semialdehidna hidrolijaza (dodavanja piruvata i ciklizacija), dapA (gen).) je enzim sa sistematskim imenom L-aspartat-4-semialdehid hidrolijaza (dodaje piruvat i ciklizuje, formira (4S)-4-hidroksi-2,3,4,5-tetrahidro-(2S)-dipikolinat).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

piruvat + L-aspartat-4-semialdehid

\rightleftharpoons

(2S,4S)-4-hidroksi-2,3,4,5-tetrahidrodipikolinat + H₂O

Istraživanja enzima iz bakterije Escherichia coli su pokazala da se raakcija može podeliti u tri konsekutivna koraka.

Reference

↑ Yugari, Y. and Gilvarg, C. (1965). „The condensation step in diaminopimelate synthesis”. J. Biol. Chem. 240: 4710-4716. PMID 5321309.
↑ Blickling, S., Renner, C., Laber, B., Pohlenz, H.D., Holak, T.A. and Huber, R. (1997). „Reaction mechanism of Escherichia coli dihydrodipicolinate synthase investigated by X-ray crystallography and NMR spectroscopy”. Biochemistry 36: 24-33. PMID 8993314.
↑ Devenish, S.R., Blunt, J.W. and Gerrard, J.A. (2010). „NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase”. J Med Chem 53: 4808-4812. PMID 20503968.
↑ Soares da Costa, T.P., Muscroft-Taylor, A.C., Dobson, R.C., Devenish, S.R., Jameson, G.B. and Gerrard, J.A. (2010). „How essential is the ’essential’ active-site lysine in dihydrodipicolinate synthase”. Biochimie 92: 837-845. PMID 20353808.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

MeSH 4-hydroxy-tetrahydrodipicolinate+synthase

[1] Yugari, Y. and Gilvarg, C. (1965). „The condensation step in diaminopimelate synthesis”. J. Biol. Chem. 240: 4710-4716. PMID 5321309.

[2] Blickling, S., Renner, C., Laber, B., Pohlenz, H.D., Holak, T.A. and Huber, R. (1997). „Reaction mechanism of Escherichia coli dihydrodipicolinate synthase investigated by X-ray crystallography and NMR spectroscopy”. Biochemistry 36: 24-33. PMID 8993314.

[3] Devenish, S.R., Blunt, J.W. and Gerrard, J.A. (2010). „NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase”. J Med Chem 53: 4808-4812. PMID 20503968.

[4] Soares da Costa, T.P., Muscroft-Taylor, A.C., Dobson, R.C., Devenish, S.R., Jameson, G.B. and Gerrard, J.A. (2010). „How essential is the ’essential’ active-site lysine in dihydrodipicolinate synthase”. Biochimie 92: 837-845. PMID 20353808.

[1]

[2]

[3]

[4]

4-Kidroksi-tetrahidrodipikolinatna sintaza

See also

Reference

Literatura

Spoljašnje veze