Fosfatidilinozitol-4-fosfat 3-kinaza

Fosfatidilinozitol-4-fosfat 3-kinaza
Identifikatori
EC broj	2.7.1.154
CAS broj	141176-94-5
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Fosfatidilinozitol-4-fosfat 3-kinaza (EC 2.7.1.154, tip II fosfoinozitid 3-kinaza, fosfoinozitid 3-kinaza sa C2 domenom, fosfoinozitidna 3-kinaza) je enzim sa sistematskim imenom ATP:1-fosfatidil-1D-mio-inozitol-4-fosfat 3-fosfotransferaza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + 1-fosfatidil-1D-mio-inozitol 4-fosfat

\rightleftharpoons

ADP + 1-fosfatidil-1D-mio-inozitol 3,4-bisfosfat

Ovaj enzim takođe fosforiliše PtdIns do PtdIns3P. Kod sisara su pznate tri izoforme.

Reference

↑ Vanhaesebroeck, B., Leevers, S.J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P.C., Woscholski, R., Parker, P.J. and Waterfield, M.D. (2001). „Synthesis and function of 3-phosphorylated inositol lipids”. Annu. Rev. Biochem. 70: 535-602. PMID 11395417.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

MeSH Phosphatidylinositol-4-phosphate+3-kinase

[1] Vanhaesebroeck, B., Leevers, S.J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P.C., Woscholski, R., Parker, P.J. and Waterfield, M.D. (2001). „Synthesis and function of 3-phosphorylated inositol lipids”. Annu. Rev. Biochem. 70: 535-602. PMID 11395417.

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