Peptidaza-1 (gnjida)

Peptidaza-1 (gnjida)
Identifikatori
EC broj	3.4.22.65
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Peptidaza-1 (gnjida) (EC 3.4.22.65, alergen Der f 1, alergen Der p 1, antigen Der p 1, antigen Eur m 1, antigen Pso o 1, glavni vašni fekalni alergen Der p 1, Der p 1, Der f 1, Eur m 1, endopeptidaza 1 (vaš)) je enzim.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Endopeptidazazno dejstvo sa širokom specifičnošću

Ovaj enzim, izveden iz kućne grinje, je glavna komponenta alergijskog imunog responsa.

Reference

↑ Meighan, P. and Pirzad, R. (2004). „Mite endopeptidase 1”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1187-1189.
↑ Kalsheker, N.A., Deam, S., Chambers, L., Sreedharan, S., Brocklehurst, K. and Lomas, D.A. (1996). „The house dust mite allergen Der p1 catalytically inactivates α1-antitrypsin by specific reactive centre loop cleavage: a mechanism that promotes airway inflammation and asthma”. Biochem. Biophys. Res. Commun. 221: 59-61. PMID 8660343.
↑ Harris, J., Mason, D.E., Li, J., Burdick, K.W., Backes, B.J., Chen, T., Shipway, A., Van Heeke, G., Gough, L., Ghaemmaghami, A., Shakib, F., Debaene, F. and Winssinger, N. (2004). „Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays”. Chem. Biol. 11: 1361-1372. PMID 15489163.
↑ Schulz, O., Sewell, H.F. and Shakib, F. (1998). „Proteolytic cleavage of CD25, the α subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity”. J. Exp. Med. 187: 271-275. PMID 9432986.
↑ Schulz, O., Sewell, H.F. and Shakib, F. (1998). „A sensitive fluorescent assay for measuring the cysteine protease activity of Der p 1, a major allergen from the dust mite Dermatophagoides pteronyssinus”. Mol. Pathol. 51: 222-224. PMID 9893750.
↑ Takai, T., Kato, T., Sakata, Y., Yasueda, H., Izuhara, K., Okumura, K. and Ogawa, H. (2005). „Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity”. Biochem. Biophys. Res. Commun. 328: 944-952. PMID 15707969.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Meighan, P. and Pirzad, R. (2004). „Mite endopeptidase 1”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1187-1189.

Spoljašnje veze

MeSH Peptidase+1+(mite)

[1] Meighan, P. and Pirzad, R. (2004). „Mite endopeptidase 1”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1187-1189.

[2] Kalsheker, N.A., Deam, S., Chambers, L., Sreedharan, S., Brocklehurst, K. and Lomas, D.A. (1996). „The house dust mite allergen Der p1 catalytically inactivates α1-antitrypsin by specific reactive centre loop cleavage: a mechanism that promotes airway inflammation and asthma”. Biochem. Biophys. Res. Commun. 221: 59-61. PMID 8660343.

[3] Harris, J., Mason, D.E., Li, J., Burdick, K.W., Backes, B.J., Chen, T., Shipway, A., Van Heeke, G., Gough, L., Ghaemmaghami, A., Shakib, F., Debaene, F. and Winssinger, N. (2004). „Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays”. Chem. Biol. 11: 1361-1372. PMID 15489163.

[4] Schulz, O., Sewell, H.F. and Shakib, F. (1998). „Proteolytic cleavage of CD25, the α subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity”. J. Exp. Med. 187: 271-275. PMID 9432986.

[5] Schulz, O., Sewell, H.F. and Shakib, F. (1998). „A sensitive fluorescent assay for measuring the cysteine protease activity of Der p 1, a major allergen from the dust mite Dermatophagoides pteronyssinus”. Mol. Pathol. 51: 222-224. PMID 9893750.

[6] Takai, T., Kato, T., Sakata, Y., Yasueda, H., Izuhara, K., Okumura, K. and Ogawa, H. (2005). „Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity”. Biochem. Biophys. Res. Commun. 328: 944-952. PMID 15707969.

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