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LP-44

LP-44, 5-HT7 serotonin reseptöründe güçlü ve seçici bir agonist görevi gören bir ilaçtır. LP-44, ilgili bileşik LP-12'den daha az seçici olsa da, araştırmalarda daha yaygın olarak kullanılmıştır ve uykunun düzenlenmesi de dahil olmak üzere beyin fonksiyonunun çeşitli yönlerinde 5-HT7 reseptörlerinin karmaşık rolünü göstermek için kullanılmıştır.[1][2][3][4]

Kaynakça

  1. ^ "The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat". Behavioural Brain Research. 191 (2): 184-9. August 2008. doi:10.1016/j.bbr.2008.03.025. PMID 18466985. 
  2. ^ "Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway". Neuroscience. 182: 71-81. May 2011. doi:10.1016/j.neuroscience.2011.02.042. PMID 21371532. 
  3. ^ Monti JM (August 2011). "Serotonin control of sleep-wake behavior". Sleep Medicine Reviews. 15 (4): 269-81. doi:10.1016/j.smrv.2010.11.003. PMID 21459634. 
  4. ^ "5-HT(1A) and 5-HT(7) receptors differently modulate AMPA receptor-mediated hippocampal synaptic transmission". Hippocampus. 22 (4): 790-801. April 2011. doi:10.1002/hipo.20940. PMID 21538661. 

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