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Naproksen

Naproksen
Klinik verisi
Gebelik
kategorisi
  • AU: POM
Uygulama
yolu		Oral
Farmakokinetik veri
Biyoyararlanım95% Oral
Protein bağlanma99%
Eliminasyon yarı ömrü12-15 Saat
Boşaltımİdrarla
Tanımlayıcılar
  • (+)-(S)-2-(6-methoxynaphthalen-2-yl)
    propanoic acid
CAS Numarası
PubChem CID
DrugBank
CompTox Bilgi Paneli (EPA)
ECHA Bilgi Kartı100.040.747 Bunu Vikiveri'de düzenleyin
Kimyasal ve fiziksel veriler
FormülC14H14O3
Mol kütlesi230.259

Naproksen bir non-steroidal anti-enflamatuar ilaçtır (NSAİİ). Hafiften orta seviyeye kadarki ağrı, ateş, enflamasyon ve osteoartrit, romatoid artrit, psoriyatik artrit, gut, yaralanma, adet krampları ve tendinit gibi durumların yol açtığı sertliklerin tedavisinde kullanılır. Ayrıca birincil dismenore tedavisinde de kullanılır. Vücutta ağrı ve enflamasyona neden olan mediatörleri azaltarak çalışır.

Her ne kadar diğer Nsaii'lara oranla daha büyük bir dozaja ihtiyaç duysa da naproksen albumine kuvvetlice bağlanır ve böylece diğer ilaçlara oranla kanda daha uzun bir yarılanma süresine sahiptir.

Naproksen'in sodyum tuzu, Naproksen sodyum, gastroinstestinal yoldan daha hızlı emilir.

Naproksen ilk kez 1976'da, reçete ilacı olarak Naprosyn adıyla satılmaya başlandı. Naproksen sodyum ise ilk kez 1980'de Anaprox ismiyle satılmaya başlandı. ABD'deki Food and Drug Administration (FDA - Gıda ve İlaç Dairesi) 1991'de ilacın reçetesiz olarak da satılmasını onaylasa da, Kanada dahil dünyanın diğer birçok ülkesinde ilaç halen reçete ilacıdır.

Yapısı ve ayrıntılar

Naproksen Nsaii'ların arilasetik asit ailesinin bir üyesidir. Beyaz kristalize bir madde olan naproksenin moleküler ağırlığı 230.2628'dir. Kokusuzdur. Ayrıca naproksen lipid çözünürdür; pratik anlamda düşük pH (pH 4'ten düşük) seviyesindeki suda çözünmez. pH seviyesi 6 veya daha yüksek olan suda çözünebilir. Erime noktası 153 °C'dır.

Yan etki ve uyarılar

Diğer NSAİİ'lar gibi naproksen de gastrointestinal yolda rahatsızlık yaratabilir. İlacı yiyecek ile birlikte almak en sık karşılaşılan bu yan etkiyi gidermeye yardımcı olabilir.

Yine diğer NSAİİ'ler gibi, naproksen sodyum ve lityum çıkartımını engelleyebilir. Lityum ilavesi (supleman) kullananlarda naproksen kullanımına dikkat edilmelidir.

Ayrıca, NSAİİ'ların salisilat ailesindeki ilaçlarla veya antikoagülanlarla beraber kullanılmaması önerilir.

Bir dönem ilaca ait beyin kanaması yapabileceği idiialarının ise gerçek dışı olduğu gösterilmiştir.[1]

Dış bağlantılar

Kaynakça

  1. ^ "Arşivlenmiş kopya". 5 Ağustos 2021 tarihinde kaynağından arşivlendi. Erişim tarihi: 5 Ağustos 2021. 

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