Alfa-amilase 1 adalah enzim yang pada manusia disandi oleh genAMY1A.[3] Gen ini ditemukan pada banyak organisme.
Amilase adalah protein yang disekresikan yang menghidrolisis ikatan 1,4-alfa-glukosida pada oligosakarida dan polisakarida, dan dengan demikian mengatalisis langkah pertama dalam pencernaan pati dan glikogen makanan. Genom manusia memiliki gugus dari beberapa gen amilase yang diekspresikan pada tingkat tinggi baik di kelenjar ludah maupun pankreas. Gen ini menyandi isoenzim amilase yang diproduksi oleh kelenjar ludah. Penyambungan alternatif menghasilkan beberapa varian transkrip yang menyandi protein yang sama.[3]
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